methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate | 1503-34-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate
• 英文别名: 2-Methylamino-3-chlor-6-amino-5-methoxycarbonyl-pyrazin；Methyl-3-amino-5-methylamino-6-chlorpyrazinoat；3-amino-6-chloro-5-methylamino-pyrazine-2-carboxylic acid methyl ester
• CAS: 1503-34-0
• 化学式: C₇H₉ClN₄O₂
• 分子量: 216.627
• InChiKey: HQBNNWNATXSQHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  90.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate 在 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate 、 caesium carbonate 、 cesium fluoride 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 6.0h， 生成 methyl 5-(methylamino)-3-[4-(3-methyl-3,8-diazabicyclo[3.2.1]octan-8-yl)anilino]-6-(3-methylimidazo[4,5-c]pyridin-7-yl)pyrazine-2-carboxylate
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
  [FR] PYRAZINE-2-CARBOXAMIDES SUBSTITUÉES UTILISÉES EN TANT QU'INHIBITEURS DE HPK1 POUR LE TRAITEMENT DU CANCER

  摘要：

  There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.

  公开号：

  WO2023001794A1
• 作为产物：
  描述：

  3-氨基-5,6-二氯-2-吡嗪羧酸甲脂 、 甲胺 以 四氢呋喃 、 甲醇 为溶剂， 以92 %的产率得到methyl 3-amino-6-chloro-5-(methylamino)pyrazine-2-carboxylate
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER
  [FR] PYRAZINE-2-CARBOXAMIDES SUBSTITUÉES UTILISÉES EN TANT QU'INHIBITEURS DE HPK1 POUR LE TRAITEMENT DU CANCER

  摘要：

  There are disclosed certain substituted pyrazine-2-carboxamides of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are inhibitors of hematopoietic progenitor kinase 1 (HPK1) and are thereby particularly useful in the treatment or prophylaxis of cancer.

  公开号：

  WO2023001794A1

文献信息

• AMINO ACID AND PEPTIDE CONJUGATES OF AMILORIDE AND METHODS OF USE THEREOF
  申请人：Gorin Fredric A.

  公开号：US20110195907A1

  公开（公告）日：2011-08-11

  The present invention provides compositions comprising amiloride amino acid and peptide conjugates. Efficient methods are also provided for administering the amiloride conjugates of the present invention for treating cancer or a central nervous system disease or disorder or for preventing or reducing ischemia-reperfusion injury. Further, kits are provided for the treatment of a central nervous system disease or disorder or for the prevention or reduction of ischemia-reperfusion injury using the amiloride conjugates of the present invention.
• US7863415B2
  申请人：——

  公开号：US7863415B2

  公开（公告）日：2011-01-04