(2-amino-4,5-dimethoxyphenyl)-(4-chlorophenyl)methanone | 886494-44-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-amino-4,5-dimethoxyphenyl)-(4-chlorophenyl)methanone
• 英文别名: (2-Amino-4,5-dimethoxyphenyl)(4-chlorophenyl)methanone
• CAS: 886494-44-6
• 化学式: C₁₅H₁₄ClNO₃
• 分子量: 291.734
• InChiKey: SHZNMJOADXEZGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-amino-4,5-dimethoxyphenyl)-(4-chlorophenyl)methanone 在 吡啶 、 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 反应 1.0h， 生成 2-[4-chlorophenyl(hydroxy)methyl]-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056
• 作为产物：
  描述：

  4-氯-3’,4’-二甲氧基二苯甲酮 在 硝酸 、 铁粉 、 溶剂黄146 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 6.5h， 生成 (2-amino-4,5-dimethoxyphenyl)-(4-chlorophenyl)methanone
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056

文献信息

• Substituted Isoquinolinones and Quinazolinones
  申请人：BERGHAUSEN Joerg

  公开号：US20110230457A1

  公开（公告）日：2011-09-22

  The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH 2 or N—R 4 and X, R 1 , R 2 , R 4 , R 6 , R 7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

  这项发明涉及公式（I）中的取代氮含有的双环杂环化合物，其中Z为CH2或N—R4，X、R1、R2、R4、R6、R7和n的定义如描述中所述。这类化合物适用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病变体。
• Aryl Ring Migration Reaction in the Synthesis of 2,4-Diaryl-4H-3,1-benzothiazines
  作者：Alexander Butin、Fatima Tsiunchik、Vladimir Abaev、Andrey Gutnov、Dmitry Cheshkov

  DOI：10.1055/s-0029-1217399

  日期：2009.8

  thiocarbamoylation reaction also takes place, and 5,11-dihydro-6H-dibenzo[b,e]azepine-5-thiones are isolated as byproducts. Factors influencing the mechanism and selectivity of the reaction are discussed. The corresponding 1-(arylmethyl)-2-isothiocyanatobenzene derivatives were also synthesized, and their behavior under Friedel-Crafts reaction conditions was investigated to confirm the crucial role

  描述了1-（二芳基甲基）-2-异硫氰酸根合苯到2,4-二芳基-4 H -3,1-苯并噻嗪衍生物的新的重排。在Friedel-Crafts条件下用三氯化铝处理起始化合物导致芳基取代基通过亲电的ipso取代机理迁移，然后环化形成3，1-苯并噻嗪环。预期的分子内硫代氨基甲酰化反应也会发生，并且5,11-dihydro-6 H -dibenzo [ b，e分离出[]氮杂-5-硫酮副产物。讨论了影响反应机理和选择性的因素。还合成了相应的1-（芳基甲基）-2-异硫氰酸根合苯衍生物，并研究了它们在Friedel-Crafts反应条件下的行为，以证实中间体二苯甲基/苄基阳离子的稳定性在确定反应过程中的关键作用。 1-（二芳基甲基）-2-异硫氰酸根合苯-Friedel-Crafts-重排-芳基迁移-3,1-苯并噻嗪
• UV/VISIBLE-ABSORBING VINYLIC MONOMERS AND USES THEREOF
  申请人：Novartis AG

  公开号：US20170242274A1

  公开（公告）日：2017-08-24

  Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

  本文描述了UV吸收乙烯基单体及其在制备能够阻挡380纳米至440纳米波长的紫外辐射和紫外辐射的UV吸收隐形眼镜中的用途，从而在一定程度上保护眼睛免受紫外辐射和潜在的紫外辐射造成的损害。
• SUBSTITUTED ISOQUINOLINONES AND QUINAZOLINONES
  申请人：Novartis AG

  公开号：US20130281473A1

  公开（公告）日：2013-10-24

  The invention relates to substituted nitrogen containing bicyclic heterocycles of the formula (I) wherein Z is CH 2 or N—R 4 and X, R 1 , R 2 , R 4 , R 6 , R 7 and n are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof.

  本发明涉及式(I)的取代氮含杂环的双环杂环化合物，其中Z是CH2或N-R4，X，R1，R2，R4，R6，R7和n的定义如说明书中所定义。这类化合物适用于治疗由MDM2和/或MDM4的活性或其变异体介导的疾病或疾病。
• UV/visible-absorbing vinylic monomers and uses thereof
  申请人：Novartis AG

  公开号：US10268053B2

  公开（公告）日：2019-04-23

  Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet (“UV”) radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

  本文描述了紫外线吸收乙烯基单体及其在制备紫外线吸收隐形眼镜中的用途，这种隐形眼镜能够阻挡波长为 380 纳米至 440 纳米的紫外线（"UV"）辐射和紫辐射，从而在一定程度上保护眼睛免受紫外线辐射和潜在紫辐射的伤害。