N-norleucyl-phenylalanine | 51163-31-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-norleucyl-phenylalanine
• 英文别名: N-Norleucyl-phenylalanin；2-(2-Aminohexanoylamino)-3-phenylpropanoic acid
• CAS: 51163-31-6；51163-32-7；103303-50-0
• 化学式: C₁₅H₂₂N₂O₃
• 分子量: 278.351
• InChiKey: FHUFGHYKLWTDAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴己酰氯 在 ammonium hydroxide 、 sodium hydroxide 作用下， 生成 N-norleucyl-phenylalanine
  参考文献：
  名称：

  Abderhalden; Schweitzer, Fermentforschung, 1930, vol. 11, p. 234

  摘要：

  DOI：

文献信息

• POLYPEPTIDE-POLYNUCLEOTIDE-COMPLEX AND ITS USE IN TARGETED EFFECTOR MOIETY DELIVERY
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2655413A1

  公开（公告）日：2013-10-30
• METHOD FOR THE SELECTION AND PRODUCTION OF TAILOR-MADE, SELECTIVE AND MULTI-SPECIFIC THERAPEUTIC MOLECULES COMPRISING AT LEAST TWO DIFFERENT TARGETING ENTITIES AND USES THEREOF
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2867255A1

  公开（公告）日：2015-05-06
• [EN] POLYPEPTIDE-POLYNUCLEOTIDE-COMPLEX AND ITS USE IN TARGETED EFFECTOR MOIETY DELIVERY<br/>[FR] COMPLEXE POLYPEPTIDE-POLYNUCLÉOTIDE ET SON UTILISATION DANS L'ADMINISTRATION D'UNE FRACTION EFFECTRICE CIBLÉE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012085111A1

  公开（公告）日：2012-06-28

  Herein is reported a polypeptide-polynucleotide-complex as therapeutic agent and its use as tool for the targeted delivery of an effector moiety. The polynucleotide part of the complex is essentially resistant to proteolytic and enzymatic degradation in vivo. Additionally the polypeptide part specifically binds to a compound or structure such as a tissue or organ, a process or a disease. Thus, one aspect as reported herein is a polypeptide-polynucleotide-complex comprising a) a polypeptide specifically binding to a target and conjugated to a first member of a binding pair, b) a polynucleotide linker conjugated at its first terminus to the second member of the binding pair, and c) an effector moiety conjugated to a polynucleotide that is complementary to at least a part of the polynucleotide linker.
• [EN] METHOD FOR THE SELECTION AND PRODUCTION OF TAILOR-MADE, SELECTIVE AND MULTI-SPECIFIC THERAPEUTIC MOLECULES COMPRISING AT LEAST TWO DIFFERENT TARGETING ENTITIES AND USES THEREOF<br/>[FR] PROCÉDÉ DE SÉLECTION ET DE PRODUCTION DE MOLÉCULES THÉRAPEUTIQUES MULTI-SPÉCIFIQUES, SÉLECTIVES ET PERSONNALISÉES COMPRENANT AU MOINS DEUX ENTITÉS DE CIBLAGE DIFFÉRENTES ET LEURS UTILISATIONS
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014001326A1

  公开（公告）日：2014-01-03

  Herein is reported a method for determining a combination of antigen binding sites comprising the steps of (i) determining the binding specificity and/or affinity and/or effector function and/or in vivo half-life of a multitude of bispecific antibodies prepared by combining each member of a first multitude of antibody Fab fragments or scFv antibody fragments with each member of a second multitude of antibody Fab fragments or scFv antibody fragments, and a linker comprising at one of its termini the second member of the first binding pair and at the respective other terminus the second member of the second binding pair, whereby the first multitude specifically binds to a first cell surface molecule and the second multitude specifically binds to a second cell surface molecule, and (ii) choosing the bispecific antibody with suitable binding specificity and/or affinity and/or effector function and/or in vivo half-life and thereby determining a combination of antigen binding sites.
• Abderhalden; Schweitzer, Fermentforschung, 1930, vol. 11, p. 234
  作者：Abderhalden、Schweitzer

  DOI：——

  日期：——