| 1208609-55-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 1208609-55-5
• 化学式: C₁₉H₁₇NO₄
• 分子量: 323.348
• InChiKey: ASNZTGARMBIYSK-UHFFFAOYSA-N

物化性质

• 沸点：
  499.8±45.0 °C(predicted)
• 密度：
  1.262±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  在 甲醇 、 sodium hydroxide 作用下， 生成 7-hydroxy-4-((methyl(phenyl)amino)methyl)-2H-chromen-2-one
  参考文献：
  名称：

  Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

  摘要：

  The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17 beta-HSD3 inhibitors are discussed. The most potent compounds from this series exhibited low nanomolar inhibitory activity with acceptable selectivity versus other 17 beta-HSD isoenzymes and nuclear receptors. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.111
• 作为产物：
  描述：

  Acetic acid 4-chloromethyl-2-oxo-2H-chromen-7-yl ester 、 N-甲基苯胺 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Coumarins as novel 17β-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer

  摘要：

  The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17 beta-HSD3 inhibitors are discussed. The most potent compounds from this series exhibited low nanomolar inhibitory activity with acceptable selectivity versus other 17 beta-HSD isoenzymes and nuclear receptors. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.111