Succinic acid mono-[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-3-yl] ester | 357399-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: Succinic acid mono-[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-3-yl] ester
• CAS: 357399-12-3
• 化学式: C₄₁H₃₈N₆O₇
• 分子量: 726.789
• InChiKey: GNXVXJOPGKHXEH-LBFZIJHGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.73
• 重原子数：
  54.0
• 可旋转键数：
  14.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  166.79
• 氢给体数：
  3.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  对硝基苯酚 、 Succinic acid mono-[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-3-yl] ester 在 吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences

  摘要：

  Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3'-->5' direction and involves coupling of 3'-Fmoc protected thiourea in the presence of HgCl2/TEA with the corresponding 5'-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00119-7
• 作为产物：
  描述：

  2'-脱氧腺苷 在 palladium on activated charcoal 吡啶 、 4-二甲氨基吡啶 、 三甲基氯硅烷 、 叠氮化锂 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 32.5h， 生成 Succinic acid mono-[(2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-({[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-methyl)-tetrahydro-furan-3-yl] ester
  参考文献：
  名称：

  Solid-Phase synthesis of positively charged deoxynucleic guanidine (DNG) oligonucleotide mixed sequences

  摘要：

  Positively charged DNG oligonucleotide mixed sequences containing A/T bases were prepared by solid-phase synthesis. Synthesis proceeds in 3'-->5' direction and involves coupling of 3'-Fmoc protected thiourea in the presence of HgCl2/TEA with the corresponding 5'-amine of the growing oligo chain. DNG binding characteristics with complementary DNA and with itself have been evaluated. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00119-7