5-[Cyclohexyl-[4-(2,6-difluorophenyl)-5-oxotetrazole-1-carbonyl]amino]-2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic acid | 1346564-28-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-[Cyclohexyl-[4-(2,6-difluorophenyl)-5-oxotetrazole-1-carbonyl]amino]-2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]benzoic acid
• CAS: 1346564-28-0
• 化学式: C₃₀H₃₅F₂N₇O₆
• 分子量: 627.648
• InChiKey: XGFLLPWQIZHNFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  45
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• TETRAZOLONES AS INHIBITORS OF FATTY ACID SYNTHASE
  申请人：BAHADOOR Adilah

  公开号：US20110274655A1

  公开（公告）日：2011-11-10

  Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof; wherein the variables R A , R B and R C are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.

  本文提供了式(I)的四唑酮FASN抑制剂或其药用可接受形式；其中变量RA、RB和RC在此处定义。本文还提供了所述化合物的药物组合物以及它们用于治疗各种疾病的方法，如过度增殖性疾病、炎症性疾病、与肥胖有关的疾病和微生物感染。
• [EN] METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] MÉTHODES DE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：YUMANITY THERAPEUTICS INC

  公开号：WO2020150423A1

  公开（公告）日：2020-07-23

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

  本公开提供了在治疗神经系统疾病中有用的化合物和方法。本发明的化合物可以单独或与其他药用活性剂结合使用，用于治疗或预防神经系统疾病。
• METHODS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：Yumanity Therapeutics, Inc.

  公开号：US20200222400A1

  公开（公告）日：2020-07-16

  The present disclosure provides compounds and methods useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.
• US8546432B2
  申请人：——

  公开号：US8546432B2

  公开（公告）日：2013-10-01
• US9346769B2
  申请人：——

  公开号：US9346769B2

  公开（公告）日：2016-05-24