1-Nitro-2--aethen | 21461-45-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-Nitro-2--aethen
• 英文别名: 9-(2-nitro-vinyl)-phenanthrene；9-(2-Nitro-vinyl)-phenanthren；9-(2-Nitroethenyl)phenanthrene
• CAS: 21461-45-0
• 化学式: C₁₆H₁₁NO₂
• 分子量: 249.269
• InChiKey: KBPMDLZIYNESQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Nitro-2--aethen 在 甲醇 、 乙醇 、 铂 作用下， 生成 2-methoxy-2-[9]phenanthryl-ethylamine
  参考文献：
  名称：

  Occupational stress in universities: Staff perceptions of the causes, consequences and moderators of stress

  摘要：

  In recent years, the Australian university sector has undergone large-scale organizational change, including restructuring, downsizing and government funding cuts. At the same tune, research front across the globe reports an alarming increase in the occupational stress experienced by university staff. We report on the first phase of a longitudinal investigation of occupational stress. A total of 22 focus groups were conducted with a representative sample of 178 academic and general staff from 15 Australian universities. The groups focused on understanding staff's experience of occupational stress, and perceptions of the sources, consequences and moderators of stress. Both general and academic staff reported a dramatic increase in stress during the previous 5 years. As a group, academic staff reported higher levels of stress than general staff. Five major or sources of stress were identified including: insufficient funding and resources; work overload; poor management practice; job insecurity; and insufficient recognition and reward. The majority of groups reported that job-related stress was having a deleterious impact on their professional work and personal welfare. Aspects of the work environment (support front co-workers and management, recognition and achievement, high morale, flexible working conditions), and personal coping strategies (stress management techniques, work/non-work balance, tight role boundaries and lowering standards), were reported to help staff cope with stress. The findings provide a timely insight into the experience of stress within universities.

  DOI：

  10.1080/02678370117944
• 作为产物：
  描述：

  9-甲醛菲 生成 1-Nitro-2--aethen
  参考文献：
  名称：

  Reichert; Wegner, Chemische Berichte, 1938, vol. 71, p. 1254,1258

  摘要：

  DOI：

文献信息

• Pd(0)-Catalyzed Chemo-, Diastereo-, and Enantioselective α-Quaternary Alkylation of Branched Aldehydes
  作者：Barry M. Trost、Zhijun Zuo、Youliang Wang、Johnathan E. Schultz

  DOI：10.1021/acscatal.0c02861

  日期：2020.8.21

  from the established chiral α-quaternary aldehyde synthesis, this project employed a chiral π-allyl–Pd complex neighboring the enolate to determine both the enantio- and diastereoselectivity. The synthetic utility of the products has been highlighted by a series of derivatizations, and the potential of this method has been extended to the synthesis of chiral α-quaternary ketones. Furthermore, this

  季碳立体中心在各种各样的有机化合物和药物分子中无处不在。由于四个不同的碳取代基之间的空间排斥，这种季碳中心的高度对映选择性构成了一个挑战。在这里，我们报告了一种新的策略，以控制由外消旋α-支化醛形成手性α-季醛的对映选择性。与已建立的手性α-季醛合成方法不同，该项目采用了与烯醇盐相邻的手性π-烯丙基-Pd配合物来确定对映体和非对映体选择性。通过一系列衍生化方法突出了产品的合成效用，该方法的潜力已扩展到手性α-季酮的合成。此外，
• Palladium-Catalyzed Regio-, Enantio-, and Diastereoselective Asymmetric [3 + 2] Cycloaddition Reactions: Synthesis of Chiral Cyclopentyl Phosphonates
  作者：Barry M. Trost、Anand H. Shinde、Youliang Wang、Zhijun Zuo、Chang Min

  DOI：10.1021/acscatal.9b05073

  日期：2020.2.7

  The palladium-catalyzed unified approach using in situ-generated Phospha-TMM species to synthesize a diverse array of chiral organophosphorus containing carbo- and heterocyclic compounds in a highly regio-, diastereo- (>20:1 dr), and enantioselective (>99% ee) fashion is being disclosed. The present protocol reveals the potential of the deprotonative phospha-TMM strategy for the synthesis of challenging

  钯催化的统一方法，使用原位产生的Phospha-TMM物质合成具有高区域，非对映体（> 20：1 dr）和对映选择性（> 99）的多种手性有机磷，其中含有碳和杂环化合物％ee）的时尚正在被披露。本协议揭示了去质子化的phospha-TMM策略的潜力，具有挑战性的五元碳环和杂环，尤其是那些具有螺环实体和季不对称立体中心的杂环。事实证明，对于本转化中所需的反应性，选择健壮的手性二酰胺基亚氨基磷酸酯配体非常关键。此外，通过多种转化，例如还原，氧化和烷基化，证明了产物的合成效用。
• Pd-Catalyzed Regio-, Diastereo-, and Enantioselective [3 + 2] Cycloaddition Reactions: Access to Chiral Cyclopentyl Sulfones
  作者：Barry M. Trost、Chuanle Zhu、Chloe Christine Ence

  DOI：10.1021/acs.orglett.1c00384

  日期：2021.4.2

  The palladium-catalyzed [3 + 2] cycloaddition using in situ generated sulfone-TMM species to construct various chiral cyclopentyl sulfones in a highly regio-, diastereo- (dr >15:1), and enantioselective (up to 99% ee) manner is reported. The present strategy can tolerate different types of sulfone-TMM donors and acceptors, and enables the construction of three chiral centers in a single step, specifically

  钯催化的[3 + 2]环加成反应，使用原位生成的砜-TMM物种以高度区域，非对映体（dr> 15：1）和对映选择性（最高ee高达99％）的方式构建各种手性环戊基砜被报道。本策略可以耐受不同类型的砜-TMM供体和受体，并且能够在单个步骤中构建三个手性中心，特别是带有带有砜部分的手性中心。强大的手性二酰胺基亚磷酸酯配体是该转化反应性和选择性的关键。
• Enantioselective Synthesis of Atropisomeric Biaryl Phosphorus Compounds by Chiral‐Phosphonium‐Salt‐Enabled Cascade Arene Formation
  作者：Lixiang Zhu、Heling Peng、Yan Guo、Jixing Che、Jia‐Hong Wu、Zhishan Su、Tianli Wang

  DOI：10.1002/anie.202202467

  日期：2022.7.25

  highly enantioselective organocatalytic cascade process has been developed for the synthesis of axially chiral 1,1′-biaryl phosphorus compounds. The approach involves multistep arene formation promoted by multifunctional phosphonium salt catalysis and proceeds through a complex Thorpe-type cycloaddition/oxidative hydroxylation/aromatization cascade with central-to-axial chirality transfer.

  已经开发了一种高度对映选择性的有机催化级联工艺，用于合成轴向手性 1,1'-联芳基磷化合物。该方法涉及由多功能鏻盐催化促进的多步芳烃形成，并通过复杂的索普型环加成/氧化羟基化/芳构化级联与中心到轴向手性转移进行。
• Reichert; Wegner, Chemische Berichte, 1938, vol. 71, p. 1254,1258
  作者：Reichert、Wegner

  DOI：——

  日期：——