2-(pyridin-2-yl)benzoyl chloride | 181132-65-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(pyridin-2-yl)benzoyl chloride
• 英文别名: 2-Pyridin-2-ylbenzoyl chloride
• CAS: 181132-65-0
• 化学式: C₁₂H₈ClNO
• 分子量: 217.655
• InChiKey: ZWWNORSNKUPWAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(pyridin-2-yl)benzoyl chloride 在 N,N-二甲基甲酰胺 sodium hydroxide 、 草酰氯 、 水 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 4.0h， 生成 2-Bromo-4-[(2-pyridin-2-yl-benzoyl)amino] benzoyl chloride
  参考文献：
  名称：

  3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES

  摘要：

  公开号：

  EP1021444B1
• 作为产物：
  描述：

  2-(2-吡啶基)苯甲酸 在 N,N-二甲基甲酰胺 草酰氯 作用下， 以 四氢呋喃 为溶剂， 反应 0.08h， 生成 2-(pyridin-2-yl)benzoyl chloride
  参考文献：
  名称：

  3-CARBOXAMIDE DERIVATIVES OF 5H-PYRROLO[2,1-c][1,4]-BENZODIAZEPINES

  摘要：

  公开号：

  EP1021444B1

文献信息

• Tricyclic benzazepine vasopressin antagonists
  申请人：American Cyanamid Company

  公开号：US05753648A1

  公开（公告）日：1998-05-19

  Tricyclic compound of the general Formula I: ##STR1## as defined herein which exhibit antagonist activity at V.sub.1 and/or V.sub.2 receptors and exhibit in vivo vasopressin antagonist activity, methods for using such compounds in treating diseases characterized by excess renal reabsorption of water, and process for preparing such compounds.

  三环化合物的一般公式I：##STR1##，如本文所述，具有V.sub.1和/或V.sub.2受体的拮抗剂活性，并在体内表现出抗利尿激素拮抗剂活性，使用这些化合物治疗以肾水过度重吸收为特征的疾病的方法，以及制备这些化合物的方法。
• Benzoheterocyclic derivatives
  申请人：Otsuka Pharmaceuticals Co., Ltd.

  公开号：US06335327B1

  公开（公告）日：2002-01-01

  A benzoheterocyclic derivative of the following formula [1]: and pharmaceutically acceptable salts thereof, which show excellent anti-vasopressin activity, vasopressin agonistic activity and oxytocin antagonistic activity, and are useful as a vasopressin antagonist, vasopressin agonist or oxytocin antagonist.

  以下是该句子的中文翻译： 一种苯并杂环衍生物，其化学式如下： 及其药用盐，表现出优异的抗加压素活性、加压素激动活性和催产素拮抗活性，可用作加压素拮抗剂、加压素激动剂或催产素拮抗剂。
• 3-Carboxamide derivatives of 5H-pyrrolo\x9b2,1-c!\x9b1,4!-benzodiazepines
  申请人：American Home Products Corporation

  公开号：US05880122A1

  公开（公告）日：1999-03-09

  This invention relates to tricyclic non-peptide vasopressin antagonists which are useful in treating conditions where decreased vasopressin levels are desired, such as in congestive heart failure, in disease conditions with excess renal water reabsorption and in conditions with increased vascular resistance and coronary vasoconstriction, the compounds having the general structure: ##STR1##

  这项发明涉及三环非肽型加压素拮抗剂，适用于治疗需要降低加压素水平的疾病状态，如充血性心力衰竭、伴有肾脏过多水分重吸收的疾病情况以及伴有增加血管阻力和冠脉收缩的疾病情况，这些化合物具有通用结构：##STR1##
• Pharmaceutically active sulfonamide derivatives as c-jun-n-terminal kinases (jnk's) inhibitors
  申请人：——

  公开号：US20040248886A1

  公开（公告）日：2004-12-09

  The present invention relates to sulfonamide derivatives of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are useful in the treatment of neuronal disorders, autoimmune diseases, cancer and cardiovascular diseases. Furthermore, said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and -3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation. Formula (I) IAr 1 is a substituted or unsubstituted aryl or heteroaryl group; X is O or S, preferably O; Ar 2 a substituted or unsubstituted arylene or heteroarylene group; R 1 and R 2 are independently selected from the group consisting of hydrogen and a C 1 -C 6 -alkyl group. 1

  本发明涉及公式（I）的磺酰胺衍生物，特别是用作药物活性化合物，以及含有这种磺酰胺衍生物的制药配方。所述磺酰胺衍生物在神经系统疾病、自身免疫疾病、癌症和心血管疾病的治疗中有用。此外，所述磺酰胺衍生物是JNK途径的有效调节剂，特别是JNK2和-3的有效和选择性抑制剂。本发明还涉及新的磺酰胺衍生物以及它们的制备方法。公式（I）中，IAr1是取代或未取代的芳基或杂环芳基基团；X是O或S，优选为O；Ar2是取代或未取代的芳烃或杂芳烃基团；R1和R2独立地选自氢和C1-C6烷基组。
• ARYLSULFONAMIDE DERIVATIVES AS C-JUN-N-TERMINAL KINASES (JNK'S) INHIBITORS
  申请人：RUECKLE Thomas

  公开号：US20100029719A1

  公开（公告）日：2010-02-04

  The present invention relates to sulfonamide derivatives of formula I notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are useful in the treatment of neuronal disorders, autoimmune diseases, cancer and cardiovascular diseases. Furthermore, said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and -3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation. Ar 1 is a substituted or unsubstituted aryl or heteroaryl group; X is O or S, preferably O; Ar 2 a substituted or unsubstituted arylene or heteroarylene group; R 1 and R 2 are independently selected from the group consisting of hydrogen and a C 1 -C 6 -alkyl group;

  本发明涉及公式I的磺酰胺衍生物，特别是用作药物活性化合物的磺酰胺衍生物，以及含有这种磺酰胺衍生物的制药配方。所述磺酰胺衍生物在治疗神经疾病、自身免疫疾病、癌症和心血管疾病方面非常有用。此外，所述磺酰胺衍生物是JNK途径的有效调节剂，它们特别是JNK2和-3的有效和选择性抑制剂。本发明还涉及新的磺酰胺衍生物以及其制备方法。其中，Ar1是取代或未取代的芳基或杂环芳基基团；X是O或S，优选O；Ar2是取代或未取代的芳烃基或杂芳烃基；R1和R2分别选自氢和C1-C6烷基组成的群。