chuktabularin I | 1227154-51-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: chuktabularin I
• CAS: 1227154-51-9
• 化学式: C₃₄H₄₂O₁₅
• 分子量: 690.698
• InChiKey: RFROFFXVDZAGOH-NCJLUWSVSA-N

反应信息

• 作为反应物：
  描述：

  chuktabularin I 、 对氯苯甲酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 反应 48.0h， 以10 mg的产率得到chuktabularin I 11,12-di-p-chlorobenzoate
  参考文献：
  名称：

  Chuktabularins E−T, 16-Norphragmalin Limonoids from Chukrasia tabularis var. velutina

  摘要：

  Chuktabularins E-T (1-16), 16 new 16-norphragmalin limonoids, together with four known compounds, chuktabularins A D, were isolated from the stem bark of Chukrasia tabularis var. veltaina. These compounds possess a biosynthetically extended propionyl or acetyl group at C-15 and a characteristic ketal moiety between the limonoid skeleton and the acyl substituent at C-15. The structures of these compounds were established on the basis of detailed spectroscopic analysis, and that of 1 was confirmed by a single-crystal X-ray diffraction experiment, representing the first verification of the skeleton of 16-norphragmalin limonoids. Chuktabularins K-O (7-11) were found to be the first 19-acetoxylated 16-norphragmalin limonoids. Variable-temperature (1)H NMR experiments suggested that 7 exists as an equilibrium mixture of conformational isomers in solution. The absolute configuration of 5 was determined by the CD exciton chirality method on its 11,12-di-p-chlorobenzoate (5a), and those of 1-4 and 6-16 were proposed by correlating with 5 spectroscopically and biogenetically.

  DOI：

  10.1021/np900734c