4-[(2-chloro-ethyl)-propyl-amino]-L-phenylalanine | 102440-98-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[(2-chloro-ethyl)-propyl-amino]-L-phenylalanine
• 英文别名: 4-[(2-Chlor-aethyl)-propyl-amino]-L-phenylalanin；(2S)-2-amino-3-[4-[2-chloroethyl(propyl)amino]phenyl]propanoic acid
• CAS: 102440-98-2
• 化学式: C₁₄H₂₁ClN₂O₂
• 分子量: 284.786
• InChiKey: YZBUMWWDGZGLAT-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环氧乙烷 、 N,N-phthaloyl-4-propylamino-L-phenylalanin-ethyl ester 在 溶剂黄146 作用下， 生成 4-[(2-chloro-ethyl)-propyl-amino]-L-phenylalanine
  参考文献：
  名称：

  19.细胞活性氨基酸和肽。第五部分对氨基和对巯基苯丙氨酸的衍生物

  摘要：

  DOI：

  10.1039/jr9590000090

文献信息

• THERAPEUTIC BENEFIT OF SUBOPTIMALLY ADMINISTERED CHEMICAL COMPOUNDS
  申请人：BROWN Dennis M.

  公开号：US20160045502A1

  公开（公告）日：2016-02-18

  The present invention describes methods and compositions for improving the therapeutic efficacy of therapeutic agents previously limited by suboptimal therapeutic performance by either improving efficacy as monotherapy or reducing side effects. Such methods and compositions are particularly applicable to mustard-based alkylating agents such as uracil mustard and analogs, derivatives, or prodrugs thereof, including 6-methyluracil mustard and 6-ethyluracil mustard.

  本发明描述了一种改善先前受到治疗性能不佳限制的治疗剂的治疗效果的方法和组合物，通过改善单药疗法的功效或减少副作用。这种方法和组合物特别适用于芥子碱基烷基化剂，例如尿嘧啶芥和其类似物、衍生物或前药，包括6-甲基尿嘧啶芥和6-乙基尿嘧啶芥。
• FULLY HUMAN ANTI-VEGF ANTIBODIES AND METHODS OF USING
  申请人：Ramachandra Sumant

  公开号：US20110097340A1

  公开（公告）日：2011-04-28

  Disclosed herein are fully human antibodies and antigen-binding fragments thereof that specifically bind human VEGF and inhibit VEGF binding to VEGF-R1 and VEGF-R2, and therefore inhibit VEGF signaling. The antibodies and antigen-binding fragments disclosed herein may be used, for example, to treat angiogenesis and conditions associated with angiogenesis both in vivo and in vitro.
• COMPOSITIONS AND METHODS FOR TREATING CANCER AND INFLAMMATION-RELATED DIESEASES AND CONDITIONS
  申请人：FIRESTONE Raymond A

  公开号：US20140364359A1

  公开（公告）日：2014-12-11

  The invention provides di-peptide conjugated antitumor agents, pharmaceutical compositions and methods for preparation and use thereof for treating various cancer and inflammation-related diseases and conditions. The present invention addresses the shortcomings of the existing anti-tumor and anti-inflammatory drugs, particularly in that the anti-tumor agents of the invention that selectively kill cancer cells with minimal damage to normal cells. Similarly, the anti-inflammatory agents of the invention provide effective treatment of various inflammatory diseases and conditions without the many deleterious side effects commonly associated with steroids
• COMPOSITIONS AND METHODS FOR CONTRACEPTION
  申请人：Firestone Raymond

  公开号：US20150335761A1

  公开（公告）日：2015-11-26

  The invention generally relates to novel compounds, compositions, devices and methods for contraception. More particularly, the invention relates to cytotoxic agents and di-peptide conjugated contraceptive agents, methods for their preparation, pharmaceutical compositions, devices and uses thereof, especially in the prevention of pregnancy.
• US8216571B2
  申请人：——

  公开号：US8216571B2

  公开（公告）日：2012-07-10