4-(2'-chloro-4'-trifluoromethyl-phenoxy)-2-nitro-anisole | 70019-48-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(2'-chloro-4'-trifluoromethyl-phenoxy)-2-nitro-anisole
• 英文别名: 2-Chloro-1-(4-methoxy-3-nitrophenoxy)-4-(trifluoromethyl)benzene
• CAS: 70019-48-6
• 化学式: C₁₄H₉ClF₃NO₄
• 分子量: 347.678
• InChiKey: GTHYGSMUPQGUEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  64.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-羟基-2-硝基茴香醚 、 3-氯-4-氟三氟甲苯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以0.62 g的产率得到4-(2'-chloro-4'-trifluoromethyl-phenoxy)-2-nitro-anisole
  参考文献：
  名称：

  [EN] TEAD INHIBITORS
  [FR] INHIBITEURS DE TEAD

  摘要：

  The present invention relates to a compound of formula (I) wherein A, Z, L, R1, R2, R3, R4, R5and R33are as defined in claim 1, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) possess utility as inhibitors of TEAD. The compounds are useful as medicaments in the treatment of diseases or conditions wherein inhibition of TEAD is desired, such as cancer and chronic pain.

  公开号：

  WO2022219246A1

文献信息

• US4349377A
  申请人：——

  公开号：US4349377A

  公开（公告）日：1982-09-14
• [EN] TEAD INHIBITORS<br/>[FR] INHIBITEURS DE TEAD
  申请人：[en]ORION CORPORATION

  公开号：WO2022219246A1

  公开（公告）日：2022-10-20

  The present invention relates to a compound of formula (I) wherein A, Z, L, R1, R2, R3, R4, R5and R33are as defined in claim 1, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) possess utility as inhibitors of TEAD. The compounds are useful as medicaments in the treatment of diseases or conditions wherein inhibition of TEAD is desired, such as cancer and chronic pain.