(4-methoxyphenyl)(1-methyl-5-nitro-1H-indol-3-yl)methanone | 141645-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (4-methoxyphenyl)(1-methyl-5-nitro-1H-indol-3-yl)methanone
• 英文别名: 3-(4-methoxy benzoyl) 1-methyl 5-nitro indole；(4-Methoxyphenyl)-(1-methyl-5-nitroindol-3-yl)methanone
• CAS: 141645-77-4
• 化学式: C₁₇H₁₄N₂O₄
• 分子量: 310.309
• InChiKey: SGRVUAFPBAPAAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Process for the preparation of Zafirlukast and analogs thereof
  申请人：Council of Scientific & Industrial Research

  公开号：US10752585B2

  公开（公告）日：2020-08-25

  The present invention relates to a process for the preparation of (1-alkylindol-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C—H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp3 C—H activation, reductive hydrogenation and amidation.

  本发明涉及一种制备（1-烷基吲哚-3-基甲基）苯甲酸衍生物，特别是扎非鲁司特及其类似物的工艺。此外，该工艺基于无保护基和 C-H 键活化策略，涉及所有步骤的催化转化序列，包括以下步骤：Sonogashira 偶联、通过 Sp3 C-H 活化形成吲哚、还原氢化和酰胺化。
• PROCESS FOR THE PREPARATION OF ZAFIRLUKAST AND ANALOGS THEREOF
  申请人：Council of Scientific & Industrial Research

  公开号：US20200216390A1

  公开（公告）日：2020-07-09

  The present invention relates to a process for the preparation of (1-alkylindo-3-ylmethyl) benzoic acid derivatives, in particular Zafirlukast and analogs thereof. Further, this process is based on protection group free and C—H bond activation strategy involving all step catalytic transformation sequence and comprises the following steps: Sonogashira coupling, indole formation by Sp 3 C—H activation, reductive hydrogenation and amidation.
• US5223510A
  申请人：——

  公开号：US5223510A

  公开（公告）日：1993-06-29