(5S)-1-(3,4-dimethoxyphenyl)-5-ethyl-7-methoxy-8-hydroxy-4-methyl-5H-2,3-benzodiazepine | 702693-86-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (5S)-1-(3,4-dimethoxyphenyl)-5-ethyl-7-methoxy-8-hydroxy-4-methyl-5H-2,3-benzodiazepine
• 英文别名: (S)-1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine；(5S)-1-(3,4-dimethoxyphenyl)-5-ethyl-7-methoxy-4-methyl-5H-2,3-benzodiazepin-8-ol
• CAS: 702693-86-5
• 化学式: C₂₁H₂₄N₂O₄
• 分子量: 368.433
• InChiKey: SHRHVSNRULCERG-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Phosphodiesterase inhibitors
  申请人：Bernard Philippe

  公开号：US20070161628A1

  公开（公告）日：2007-07-12

  The invention relates especially to novel stereospecific derivatives of 2,3-benzodiazepine type as inhibitors of phosphodiesterases, especially 2 and 4, and uses thereof in the therapeutic field, most particularly for preventing and treating pathologies involving a central and/or peripheral disorder. The compounds of the invention more particularly correspond to the general formulae (I) and (II):

  该发明特别涉及2,3-苯二氮䓬啶类的新立体特异性衍生物，作为磷酸二酯酶，特别是2和4的抑制剂，以及在治疗领域中的用途，尤其是用于预防和治疗涉及中枢和/或外周障碍的病理。该发明的化合物更特别地对应于一般式(I)和(II)：
• Modulation of dopamine responses with substituted (S)-2,3-benzodiazepines
  申请人：——

  公开号：US20040254173A1

  公开（公告）日：2004-12-16

  Compounds according to formula I: 1 wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein, and wherein the compound comprises the (S)-enantiomer, administered for modulation of dopamine responses and treatment of dopamine-mediated disorders.

  根据公式I：1中R1、R2、R3、R4、R5和R6的定义，其中化合物包括(S)-对映体，用于调节多巴胺反应和治疗多巴胺介导的疾病。
• Method of lowering body temperature with (S)-2,3-benzodiazepines
  申请人：Vela Pharmaceuticals, Inc.

  公开号：US20040229866A1

  公开（公告）日：2004-11-18

  1 An (S)-2,3-benzodiazepine of Formula I, substantially isolated from the corresponding (R)-enantiomer thereof, is administered to lower the body temperature of an individual.

  将从相应的(R)-对映体中基本上分离出来的Formula I的(S)-2,3-苯二氮䓬片，被用于降低个体的体温。
• Method of lowering body temperature with (R) - 2,3-benzodiazepines
  申请人：——

  公开号：US20040224943A1

  公开（公告）日：2004-11-11

  An (R)-2,3-benzodiazepine of Formula I, substantially isolated from the corresponding (S)-enantiomer thereof, is administered to lower the body temperature of an individual. 1

  公式I的(R)-2,3-苯二氮䓬被从对应的(S)-对映体中基本上分离出来，被用于降低个体的体温。
• Pharmaceutical composition of 1- (3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
  申请人：Vela Pharmaceuticals, Inc.

  公开号：US20040157833A1

  公开（公告）日：2004-08-12

  Pharmaceutical compositions comprising 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine; or a pharmaceutically acceptable salt thereof. The compositions are used for treating, preventing or delaying the onset of disorders mediated by LTB 4 , TXA 2 or adenosine.

  药物组合物包括1-(3,4-二甲氧基苯基)-4-甲基-5-乙基-7-甲氧基-8-羟基-5H-2,3-苯并二氮平，或其药学上可接受的盐。该组合物用于治疗、预防或延缓由LTB4、TXA2或腺苷介导的疾病的发作。