4,6-Diethyl-2,3-dihydrothieno<2,3-c>furan | 100103-53-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4,6-Diethyl-2,3-dihydrothieno<2,3-c>furan
• 英文别名: 4,6-diethyl-2,3-dihydrothieno[2,3-c]furan
• CAS: 100103-53-5
• 化学式: C₁₀H₁₄OS
• 分子量: 182.287
• InChiKey: IZMINQOWWBOMSR-UHFFFAOYSA-N

物化性质

• 沸点：
  240.5±39.0 °C(Predicted)
• 密度：
  1.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  38.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(4-Brom-3-furyl)ethanol 在 正丁基锂 、 四溴化碳 、 叔丁基锂 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 14.08h， 生成 4,6-Diethyl-2,3-dihydrothieno<2,3-c>furan
  参考文献：
  名称：

  Gorzynsky, Marek; Rewicki, Dieter, Liebigs Annalen der Chemie, 1986, # 4, p. 625 - 637

  摘要：

  DOI：

文献信息

• NOVEL THIOPHENE COMPOUND AND PROCESS FOR PRODUCING CAFFENOFURAN OR ANALOGUE THEREOF FROM THE SAME
  申请人：SAN-EI GEN F.F.I., INC.

  公开号：EP1854791B1

  公开（公告）日：2011-07-13
• GORZYNSKI, M.;REWICKI, D., LIEBIGS ANN. CHEM., 1986, N 4, 625-637
  作者：GORZYNSKI, M.、REWICKI, D.

  DOI：——

  日期：——
• Novel Thiophene Compound and Process for Producing Caffenofuran or Analogue Thereof from the Same
  申请人：Katsumura Shigeo

  公开号：US20080167481A1

  公开（公告）日：2008-07-10

  The present invention provides a novel thiophene compound as a synthetic intermediate that is useful for efficient production of kahweofuran or an analogue thereof. The present invention also provides a process for producing kahweofuran or an analogue thereof using the novel thiophene compound as an intermediate material. Of novel thiophene compounds represented by Formula (1): wherein R 1 is a hydrogen atom or a C 1 -C 4 lower alkyl group; R 2 is a hydrogen atom or an alcohol-protecting group; R 3 is a hydrogen atom, —COR 4 or —C(OH)R 5 (wherein R 4 and R 5 each represent a C 1 -C 4 lower alkyl group); provided that when R 2 and R 3 are hydrogen atoms, R 1 is not any of a hydrogen atom, methyl group, or n-propyl group; a thiophene compound represented by Formula (2) is reduced and cyclized in the presence of a transition metal catalyst to produce kahweofuran or kahweofuran analogue (3 a ) shown below: wherein R 1 is a hydrogen atom or a C 1 -C 4 lower alkyl group, and R 4 is a C 1 -C 4 lower alkyl group.
• US7897790B2
  申请人：——

  公开号：US7897790B2

  公开（公告）日：2011-03-01
• Gorzynsky, Marek; Rewicki, Dieter, Liebigs Annalen der Chemie, 1986, # 4, p. 625 - 637
  作者：Gorzynsky, Marek、Rewicki, Dieter

  DOI：——

  日期：——