4-[3-(4-甲脒基-2-甲氧基苯氧基)丙氧基]-3-甲氧基苯甲脒 | 124076-65-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 4-[3-(4-甲脒基-2-甲氧基苯氧基)丙氧基]-3-甲氧基苯甲脒
• 英文名称: 1,3-bis(4-amidino-2-methoxyphenoxy)propane
• 英文别名: DAMP；4-[3-(4-carbamimidoyl-2-methoxyphenoxy)propoxy]-3-methoxybenzenecarboximidamide
• CAS: 124076-65-9
• 化学式: C₁₉H₂₄N₄O₄
• 分子量: 372.424
• InChiKey: YBEQGLWWCCCCRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  137
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-羟基-3-甲氧基苯甲腈 在 盐酸 、 氨 、 sodium ethanolate 作用下， 以 苯 为溶剂， 反应 126.0h， 生成 4-[3-(4-甲脒基-2-甲氧基苯氧基)丙氧基]-3-甲氧基苯甲脒
  参考文献：
  名称：

  Analogs of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia

  摘要：

  A series of 33 analogues of the anti-Pneumocystis carinii drug 1,5-bis(4-amidinophenoxy)pentane (pentamidine) was synthesized for screening against a rat model of P. carinii pneumonia (PCP). Twenty-five of the compounds showed efficacy against PCP when compared to a saline-treated control group. Two compounds, 1,4-bis(4-amidinophenoxy)butane (butamidine, 6) and 1,3-bis(4-amidino-2-methoxyphenoxy)propane (DAMP, 16), were statistically more effective than the parent drug in treating PCP in the rat model of infection. In addition to their activity against PCP, the compounds were also evaluated for antitrypsin activity, ability to inhibit thymidylate synthetase, affinity for DNA, and toxicity. No correlation was observed between the tested molecular interactions of the diamidines and their effectiveness against PCP.

  DOI：

  10.1021/jm00166a026

文献信息

• Benzamidoxime prodrugs as antipneumocystic agents
  申请人：THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP1561463A2

  公开（公告）日：2005-08-10

  A compound of Formula II: wherein: R1 and R2are each independently selected from the group consisting of H, loweralkyl, oxyalkyl, alkoxyalkyl, cycloalkyl, aryl, hydroxyalkyl, aminoalkyl or alkylaminoalkyl; R3is H, loweralkyl, oxyalkyl, alkoxyalkyl, hydroxyalkyl, cycloalkyl, aryl, aminoalkyl, alkylaminoalkyl or halogen; R4 is-OY, or R1 and R4 together represent and A is a heterocyclic aromatic group.

  式 II 的化合物： 其中 R1 和 R2 各自独立地选自 H、低级烷基、氧基烷基、烷氧基烷基、环烷基、芳基、羟基烷基、氨基烷基或烷基氨基烷基组成的组； R3 是 H、低级烷基、氧代烷基、烷氧基烷基、羟基烷基、环烷基、芳基、氨基烷基、烷基氨基烷基或卤素； R4 是-OY，或 R1 和 R4 共同代表 和 A 是杂环芳基。
• Combinations of drugs (e.g., a benzimidazole and pentamidine) for the treatment of neoplastic disorders
  申请人：——

  公开号：US20020165261A1

  公开（公告）日：2002-11-07

  The invention features a method for treating a patient having a cancer or other neoplasm, by administering to the patient (i) a benzimidazole or a metabolite or analog thereof; and (ii) pentamidine or a metabolite or analog thereof simultaneously or within 14 days of each other in amounts sufficient to inhibit the growth of the neoplasm.

  本发明的特点是一种治疗癌症或其他肿瘤患者的方法，其方法是同时或在 14 天内向患者施用(i) 苯并咪唑或其代谢物或类似物；(ii) 戊脒或其代谢物或类似物，其用量足以抑制肿瘤的生长。
• Combinations of drugs for the treatment of neoplastic disorders
  申请人：——

  公开号：US20030166642A1

  公开（公告）日：2003-09-04

  The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient two compounds simultaneously or within 14 days of each other in amounts sufficient to treat the patient.

  本发明的特征是一种治疗癌症或其他肿瘤患者的方法，通过同时或在 14 天内给患者施用两种化合物，其用量足以治疗患者。
• BENZAMIDOXIME PRODRUGS AND USE THEREOF FOR TREATING PNEUMONIA
  申请人：THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP0861071B1

  公开（公告）日：2005-05-11
• COMBINATIONS OF DRUGS (E.G., CHLORPROMAZINE AND PENTAMIDINE) FOR THE TREATMENT OF NEOPLASTIC DISORDERS
  申请人：Combinatorx, Incorporated

  公开号：EP1339399A2

  公开（公告）日：2003-09-03