4-[3-(甲磺酰氧基)丙基]哌嗪-1-羧酸叔丁酯盐酸盐 | 1630906-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-[3-(甲磺酰氧基)丙基]哌嗪-1-羧酸叔丁酯盐酸盐
• 英文名称: tert-butyl 4-(3-((methylsulfonyl)oxy)propyl)piperazine-1-carboxylate hydrochloride
• 英文别名: Tert-butyl 4-[3-(methanesulfonyloxy)propyl]piperazine-1-carboxylate hydrochloride；tert-butyl 4-(3-methylsulfonyloxypropyl)piperazine-1-carboxylate;hydrochloride
• CAS: 1630906-98-7
• 化学式: C₁₃H₂₆N₂O₅S*(x)ClH
• 分子量: 358.88
• InChiKey: IAYLHXGKUONMPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.33
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  84.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-[3-(甲磺酰氧基)丙基]哌嗪-1-羧酸叔丁酯盐酸盐 在 N-氯代丁二酰亚胺 、 potassium carbonate 、 溶剂黄146 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 二甲基亚砜 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 80.0h， 生成 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one maleate
  参考文献：
  名称：

  [EN] PROCESSES FOR PREPARING AN FGFR INHIBITOR
  [FR] PROCÉDÉS DE PRÉPARATION D'UN INHIBITEUR DE FGFR

  摘要：

  披露了本发明的是制备8-(3-(4-丙烯酰基哌嗪-l-基)丙基)-6-(2,6-二氯-3,5-二甲氧基苯基)-2-(甲基氨基)吡啶[2,3-d]嘧啶-7(8H)-酮和FGFR抑制剂的过程，以及它们的的多晶型物和/或盐型。

  公开号：

  WO2017027567A1

文献信息

• Processes for preparing an FGFR inhibitor
  申请人：Principia Biopharma, Inc.

  公开号：US10899760B2

  公开（公告）日：2021-01-26

  Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.

  本文公开了制备 8-(3-(4-丙烯酰基哌嗪-1-基)丙基)-6-(2,6-二氯-3,5-二甲氧基苯基)-2-(甲基氨基)吡啶并[2,3-d]嘧啶-7(8H)-酮和 FGFR 抑制剂及其多晶型和/或盐形式的工艺。
• Composition and method for dual targeting in treatment of neuroendocrine tumors
  申请人：NANOPHARMACEUTICALS LLC

  公开号：US11351137B2

  公开（公告）日：2022-06-07

  Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.

  化学组合物及其合成方法。本文公开和描述的组合物是针对与去甲肾上腺素转运体（NET）或儿茶酚胺转运体靶标共轭的甲状腺激素αvβ3整合素受体拮抗剂。这些组合物在神经内分泌肿瘤的治疗和诊断成像中具有双重靶向效应，并提高了靶向效率。
• PROCESSES FOR PREPARING AN FGFR INHIBITOR
  申请人：Principia Biopharma, Inc.

  公开号：US20180215756A1

  公开（公告）日：2018-08-02

  Disclosed herein are processes for preparing 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one and FGFR inhibitor, as well as polymorphs and/or salt forms thereof.
• COMPOSITION AND METHOD FOR DUAL TARGETING IN TREATMENT OF NEUROENDOCRINE TUMORS
  申请人：NANOPHARMACEUTICALS LLC

  公开号：US20210299262A1

  公开（公告）日：2021-09-30

  Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.
• [EN] COMPOSITION AND METHOD FOR DUAL TARGETING IN TREATMENT OF NEUROENDOCRINE TUMORS<br/>[FR] COMPOSITION ET MÉTHODE DE DOUBLE CIBLAGE DANS LE TRAITEMENT DE TUMEURS NEUROENDOCRINES
  申请人：[en]NANOPHARMACEUTICALS LLC

  公开号：WO2022260918A1

  公开（公告）日：2022-12-15

  Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone ανβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.