3-(1H-benzoimidazol-2-ylmethyl)-2-[4-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-piperazin-1-ylmethyl]-3H-imidazo[4,5-b]pyridine | 692773-06-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 3-(1H-benzoimidazol-2-ylmethyl)-2-[4-(5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonyl)-piperazin-1-ylmethyl]-3H-imidazo[4,5-b]pyridine
• 英文别名: 3-(1H-benzimidazol-2-ylmethyl)-2-[[4-(5-chloro-1,3-dimethylpyrazol-4-yl)sulfonylpiperazin-1-yl]methyl]imidazo[4,5-b]pyridine
• CAS: 692773-06-1
• 化学式: C₂₄H₂₆ClN₉O₂S
• 分子量: 540.049
• InChiKey: WXTLQHYJFIYVOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  126
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Hetero-substituted benzimidazole compounds and antiviral uses thereof
  申请人：——

  公开号：US20040166137A1

  公开（公告）日：2004-08-26

  The present invention relates to novel hetero-substituted benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses hetero-substituted benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of hetero-substituted benzimidazole compounds as inhibitors of membrane fusion associated events, such as viral transmission. In another embodiment, the invention encompasses processes for making hetero-substituted benzimidazole compounds, methods of using the hetero-substituted benzimidazole compounds and compositions comprising the hetero-substituted benzimidazole compounds. Finally, the invention provides methods for treating, preventing or ameliorating symptoms associated with respiratory infection, particularly that caused by Respiratory Syncytial Virus utilizing the novel benzimidazole compounds of the invention.

  本发明涉及一种具有有用的抗病毒活性的新型杂代取代苯并咪唑化合物。更具体地说，本发明涵盖了抑制与膜融合相关事件（如病毒传播）、减少病毒载量或以其他方式治疗病毒感染的杂代取代苯并咪唑化合物。本发明还涵盖了将杂代取代苯并咪唑化合物用作抑制与膜融合相关事件（如病毒传播）的抑制剂。在另一实施例中，本发明涵盖了制备杂代取代苯并咪唑化合物的方法，使用杂代取代苯并咪唑化合物的方法以及包含杂代取代苯并咪唑化合物的组合物。最后，本发明提供了使用本发明的新型苯并咪唑化合物治疗、预防或缓解与呼吸道感染有关的症状，特别是由呼吸合胞病毒引起的感染的方法。
• [EN] HETERO-SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AND ANTIVIRAL USES THEREOF<br/>[FR] COMPOSES DE BENZIMIDAZOLE A SUBSTITUTION HETERO ET UTILISATIONS ANTIVIRALES DE CES COMPOSES
  申请人：TRIMERIS INC

  公开号：WO2004043913A2

  公开（公告）日：2004-05-27

  The present invention relates to novel hetero-substituted benzimidazole compounds that have useful antiviral activity. More specifically, the invention encompasses hetero-substituted benzimidazole compounds that inhibit membrane fusion associated events such as viral transmission, reduce viral load or otherwise treat viral infections. The invention also encompasses the use of hetero-substituted benzimidazole compounds as inhibitors of membrane fusion associated events, such as viral transmission. In another embodiment, the invention encompasses processes for making hetero-substituted benzimidazole compounds, methods of using the hetero-substituted benzimidazole compounds and compositions comprising the hetero-substituted benzimidazole compounds. Finally, the invention provides methods for treating, preventing or ameliorating symptoms associated with respiratory infection, particularly that caused by Respiratory Syncytial Virus utilizing the novel benzimidazole compounds of the invention.