(S,E)-1-(4-methoxyphenyl)-N-(1-phenylethyl)butan-1-imine | 1233132-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S,E)-1-(4-methoxyphenyl)-N-(1-phenylethyl)butan-1-imine
• CAS: 1233132-55-2
• 化学式: C₁₉H₂₃NO
• 分子量: 281.398
• InChiKey: QSHDXIAOMDVNBP-CVTQAYBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.05
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  21.59
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  (S)-(-)- α-甲基苄胺 、 4'-甲氧基苯丁酮 在 titanium(IV) isopropylate 作用下， 以 甲苯 为溶剂， 生成 、 (S,E)-1-(4-methoxyphenyl)-N-(1-phenylethyl)butan-1-imine
  参考文献：
  名称：

  Highly Diastereoselective Hydrogenation of Imines by a Bimetallic Pd−Cu Heterogeneous Catalyst

  摘要：

  An efficient and practical heterogeneous bimetallic Pd-Cu/C catalyst was identified as an alternative to Raney nickel for the highly diastereoselective hydrogenation of imines prepared from prochiral ketones and alpha-phenylethylamines. Chiral amines were obtained with diastereomeric excess (de) up to 94% using Pd-Cu/C, while conventional Pd-C catalysts afforded only 72% de. Optimization showed that a robust process required a palladium/copper ratio of 4:1. Evidence for the influence of catalyst pretreatment which may change the structure of the catalyst and/or metal oxidation states on the selectivity of the reaction is discussed. The bimetallic catalyst system provided consistent results on scale and performed reliably on a variety of substrates.

  DOI：

  10.1021/op1001325