4-[4-[4-(1,1,3-三氧代-1,2-苯并噻唑-2-基)丁基]哌嗪-1-基]-1H-吲哚-2-羧酸甲酯 | 141533-35-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 4-[4-[4-(1,1,3-三氧代-1,2-苯并噻唑-2-基)丁基]哌嗪-1-基]-1H-吲哚-2-羧酸甲酯
• 英文名称: methyl 4-[4-[4-(1,1,3-trioxo-1,2-benzothiazol-2-yl)butyl]piperazin-1-yl]-1H-indole-2-carboxylate
• CAS: 141533-35-9
• 化学式: C₂₅H₂₈N₄O₅S
• 分子量: 496.6
• InChiKey: LPPRLWFUMJHAKF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  35
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Methods of Suppressing Appetite by the Administration of Antagonists of the Serotonin HTR1a or HTR2b Receptors or Inhibitors of TPH2
  申请人：Karsenty Gerard

  公开号：US20120115778A1

  公开（公告）日：2012-05-10

  Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.
• [EN] METHODS OF SUPPRESSING APPETITE BY THE ADMINISTRATION OF ANTAGONISTS OF THE SEROTONIN HTR1a or HTR2b RECEPTORS OR INHIBITORS OF TPH2<br/>[FR] PROCÉDÉS DE SUPPRESSION DE L'APPÉTIT PAR L'ADMINISTRATION D'ANTAGONISTES DES RÉCEPTEURS HTR1A OU HTR2B DE LA SÉROTONINE OU D'INHIBITEURS DE TPH2
  申请人：UNIV COLUMBIA

  公开号：WO2011009012A1

  公开（公告）日：2011-01-20

  Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.