{[(Bis-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-carbamoyl)-methyl]-tert-butoxycarbonyl-amino}-acetic acid | 153996-25-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: {[(Bis-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-carbamoyl)-methyl]-tert-butoxycarbonyl-amino}-acetic acid
• 英文别名: 2-[[2-[bis[2-[3-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]propoxy]-2-oxoethyl]amino]-2-oxoethyl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]acetic acid
• CAS: 153996-25-9
• 化学式: C₅₃H₆₀N₆O₁₅
• 分子量: 1021.09
• InChiKey: ZQROBPAFUSDHEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  74
• 可旋转键数：
  30
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  275
• 氢给体数：
  5
• 氢受体数：
  15

反应信息

• 作为反应物：
  描述：

  {[(Bis-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-carbamoyl)-methyl]-tert-butoxycarbonyl-amino}-acetic acid 在 protected tryptophan 作用下， 生成 (S)-2-Amino-N-[(3-hydroxy-propylcarbamoyl)-methyl]-3-(1H-indol-3-yl)-propionamide
  参考文献：
  名称：

  Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support

  摘要：

  A linker based on the combination of two molecules of iminodiacetic acid that allows for the release of peptide molecule from the polymeric bead in two equimolar portions in two distinct steps was designed and synthesized and its predicted properties were verified.

  DOI：

  10.1016/s0040-4039(00)79300-2
• 作为产物：
  描述：

  (9H-fluoren-9-yl)methyl {(3-hydroxypropylcarbamoyl)methyl}carbamate 在 4-二甲氨基吡啶 、 达卡巴嗪 、 三氟乙酸 作用下， 生成 {[(Bis-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-carbamoyl)-methyl]-tert-butoxycarbonyl-amino}-acetic acid
  参考文献：
  名称：

  Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support

  摘要：

  A linker based on the combination of two molecules of iminodiacetic acid that allows for the release of peptide molecule from the polymeric bead in two equimolar portions in two distinct steps was designed and synthesized and its predicted properties were verified.

  DOI：

  10.1016/s0040-4039(00)79300-2

文献信息

• Combinatorial chemistry and natural products. Teicoplanin aglycone as a molecular scaffold for solid phase synthesis of combinatorial libraries
  作者：Pierfausto Seneci、Christine Sizemore、Khalid Islam、Peter Kocis

  DOI：10.1016/0040-4039(96)01350-0

  日期：1996.8

  Teicoplanin aglycone 1 has been linked to a solid support via two different double cleavable linkers. The attachment was realized selectively on the 38COOH function of 1. Two molecules of 1 were attached on each linker moiety and could be separately released with different mechanisms. The release properties of the resin bound entities were determined by means of analytical and biological characterization

  Teicoplanin糖苷配基1已通过两个不同的双可裂解接头与固体支持物相连。附着是选择性地实现1的38 COOH功能。两个1的分子附着在每个接头部分上，并可以通过不同的机制分别释放。通过分析和生物学表征确定树脂结合的实体的释放性质。