({3-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-amino)-acetic acid 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propyl ester | 167628-65-1

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: ({3-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-amino)-acetic acid 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propyl ester
• CAS: 167628-65-1
• 化学式: C₄₄H₄₇N₅O₁₀
• 分子量: 805.885
• InChiKey: UKHIWRNHXDAUJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.75
• 重原子数：
  59.0
• 可旋转键数：
  20.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  199.49
• 氢给体数：
  5.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  tert-butyl 2,6-dioxomorpholine-4-carboxylate 、 ({3-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-amino)-acetic acid 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propyl ester 生成 {[(Bis-{3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-carbamoyl)-methyl]-tert-butoxycarbonyl-amino}-acetic acid
  参考文献：
  名称：

  Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support

  摘要：

  A linker based on the combination of two molecules of iminodiacetic acid that allows for the release of peptide molecule from the polymeric bead in two equimolar portions in two distinct steps was designed and synthesized and its predicted properties were verified.

  DOI：

  10.1016/s0040-4039(00)79300-2
• 作为产物：
  描述：

  (9H-fluoren-9-yl)methyl {(3-hydroxypropylcarbamoyl)methyl}carbamate 在 4-二甲氨基吡啶 、 达卡巴嗪 、 三氟乙酸 作用下， 生成 ({3-[2-(9H-Fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propoxycarbonylmethyl}-amino)-acetic acid 3-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-acetylamino]-propyl ester
  参考文献：
  名称：

  Symmetrical structure allowing the selective multiple release of a defined quantity of peptide from a single bead of polymeric support

  摘要：

  A linker based on the combination of two molecules of iminodiacetic acid that allows for the release of peptide molecule from the polymeric bead in two equimolar portions in two distinct steps was designed and synthesized and its predicted properties were verified.

  DOI：

  10.1016/s0040-4039(00)79300-2