5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-(2,2,2-trifluoroethyl)-2,3-dihydroindole-1-carboxamide | 1187517-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazol-3-yl]-N-(2,2,2-trifluoroethyl)-2,3-dihydroindole-1-carboxamide
• CAS: 1187517-51-6
• 化学式: C₂₁H₁₅Cl₂F₆N₃O₂
• 分子量: 526.265
• InChiKey: FYMRWDCJCBJKSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  53.9
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• [EN] METHODS OF CONTROLLING INSECTS<br/>[FR] PROCÉDÉS DE LUTTE CONTRE LES INSECTES
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014029707A1

  公开（公告）日：2014-02-27

  The present invention provides a method comprising applying to a crop of rice plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein -B1-Β2-Β3- is -C=N-O-, -C=N-CH2-, or -N-CH2-CH2-; providing that when A is A1 -B1-Β2-Β3- is -C=N-CH2- or -N-CH2-CH2-, when A is A2 -B1-Β2-Β3- is -C=N-O- or -N-CH2-CH2-, and when A is A3 -B1-B2-B3- is -C=N-O-; R1 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl; R2 is group (X) X2 is C-X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least one of X1, X3 and X 6 : is not hydrogen; A is selected from (A1) to (A5) Y1 is C-R6, CH or nitrogen; Y2 and Y3 are independently CH or nitrogen; wherein no more than two of Y1, Y2 and Y3 are nitrogen and wherein Y2 and Y3 are not both nitrogen; R5 is hydrogen, halogen, cyano, nitro, NH2, C1-C4alkyl, C1-C4haloalkyl, C3-C5cycloalkyl, C3-C5halocycloalkyl, C1-C2alkoxy, or C1-C2haloalkoxy; providing that when A is A3 or A4, R5 is not hydrogen; R6 when present together with R5 forms a -CH=CH-CH=CH- bridge; R7 is C1-C4alkyl; R8 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy(C1-C4)alkyl, C1-C4alkylthio(C1-C4)alkyl, C1-C4alkylsulfmyl(C1-C4)alkyl, C1-C4alkylsulfonyl(C1-C4)alkyl, C3-C6cycloalkyl, C3-C6cycloalkyl(C1-C4)alkyl-, or tetrahydrofuranyl; R9 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkyl-O-CH2-, C1-C4haloalkyl-O-CH2-,C3-C6cycloalkyl, C3- C6cycloalkyl-CH2, C1-C4alkyl-S-CH2-, C1-C4alkyl-S(O)-CH2-, or C1-C4alkyl-S(O)-CH2; each Z is independently halogen, C1-C12alkyl or C1-C12alkyl substituted by one to five R12, nitro, C1-C12alkoxy or C1-C12alkoxy substituted by one to five R12 cyano, C1-C12alkylsulfinyl, C1-C12alkylsulfonyl, C1-C12haloalkylsulfinyl, C1-C12haloalkylsulfonyl, hydroxyl or thiol; each R12 is halogen, cyano, nitro, hydroxy, C1-C8alkoxy-, C1-C8haloalkoxy-, mercapto, C1-C8alkylthio-, or C1-C8haloalkylthio; and k is 0, 1,2 or 3.

  本发明提供了一种方法，包括将式（I）的化合物施用于水稻植株、其基因座或繁殖材料，其中-B1-Β2-Β3-为-C=N-O-，-C=N-CH2-或-N- - -；当A为A1时，-B1-Β2-Β3-为-C=N- -或-N- - -，当A为A2时，-B1-Β2-Β3-为-C=N-O-或-N- - -，当A为A3时，-B1-B2-B3-为-C=N-O-；R1为三氟甲基、二氟甲基或氯二氟甲基；R2为基团（X），X2为C-X6或氮；X1、X3和X6独立地为氢、卤素或三卤甲基，其中X1、X3和X6中至少有一个不是氢；A从（A1）到（A5）中选择，Y1为C-R6、CH或氮；Y2和Y3独立地为CH或氮；其中Y1、Y2和Y3中不超过两个为氮，且Y2和Y3不同时为氮；R5为氢、卤素、氰基、硝基、NH2、C1-C4烷基、C1-C4卤代烷基、C3-C5环烷基、C3-C5卤代环烷基、C1-C2烷氧基或C1-C2卤代烷氧基；当A为A3或A4时，R5不是氢；R6与R5一起形成一个-CH=CH-CH=CH-桥；R7为C1-C4烷基；R8为C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧（C1-C4）烷基、C1-C4烷硫（C1-C4）烷基、C1-C4烷基磺（C1-C4）烷基、C1-C4烷基磺酰（C1-C4）烷基、C3-C6环烷基、C3-C6环烷基（C1-C4）烷基或四氢呋喃基；R9为C1-C4烷基、C1-C4卤代烷基、C1-C4烷氧- -、C1-C4卤代烷氧- -、C3-C6环烷基、C3-C6环烷基- -、C1-C4烷硫- -、C1-C4烷硫酰- -或C1-C4烷硫酰- -；每个Z独立地为卤素、C1-C12烷基或被1至5个R12、硝基、C1-C12烷氧基或被1至5个R12氰基、C1-C12烷基亚硝基、C1-C12烷基磺酰基、C1-C12烷基磺酰基、C1-C12卤代烷基磺酰基、C1-C12卤代烷基磺酰基、羟基或硫醇取代的C1-C12烷氧基；每个R12为卤素、氰基、硝基、羟基、C1-C8烷氧基、C1-C8卤代烷氧基、巯基、C1-C8烷硫基或C1-C8卤代烷硫基；k为0、1、2或3。
• METHODS OF PEST CONTROL IN SOYBEAN
  申请人：Syngenta Participations AG

  公开号：US20150152070A1

  公开（公告）日：2015-06-04

  The invention provides methods comprising applying to a crop of soybean plants, the locus thereof, or propagation material thereof, a compound of formula (I) wherein —B 1 —B 2 —B 3 — is —C═N—O—, —C═N—CH 2 — or —N—CH 2 —CH 2 —; Y 1 , Y 2 and Y 3 are independently CH or nitrogen; wherein no more than two of Y 1 , Y 2 and Y 3 are nitrogen and wherein Y 2 and Y 3 are not both nitrogen; R 9 is C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, C 1 -C 4 alkyl-O—CH 2 —, C 1 -C 4 haloalkyl-O—CH 2 —, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl-CH 2 —, C 1 -C 4 alkyl-S—CH 2 —, C 1 -C 4 alkyl-S(O)—CH 2 —, or C 1 -C 4 alkyl-S(O 2 )—CH 2 —; X 2 is C—X 6 or nitrogen; X 1 , X 3 and X 6 are independently hydrogen, halogen or trihalomethyl, wherein at least two of X 1 , X 3 and X 6 are not hydrogen; X 4 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl. Preferably the methods are for control of stinkbugs, in particular from the genus Euschistus and in particular the species Euschistus heros .

  本发明提供了一种方法，包括将式(I)化合物应用于大豆植株、其基因座或繁殖材料中，其中-B1-B2-B3-为-C═N-O-、-C═N-CH2-或-N- - -；Y1、Y2和Y3独立地为CH或氮；其中不超过两个Y1、Y2和Y3为氮，且Y2和Y3不都为氮；R9为C1-C4烷基、C1-C4卤代烷基、C1-C4烷基-O- -、C1-C4卤代烷基-O- -、C3-C6环烷基、C3-C6环烷基- -、C1-C4烷基-S- -、C1-C4烷基-S(O)- -或C1-C4烷基-S(O2)- -；X2为C-X6或氮；X1、X3和X6独立地为氢、卤素或三卤甲基，其中至少两个X1、X3和X6不是氢；X4为三氟甲基、二氟甲基或氯二氟甲基。该方法通常用于控制臭虫，特别是Euschistus属和特别是Euschistus heros种。
• [EN] METHODS OF SOIL PEST CONTROL<br/>[FR] PROCÉDÉS DE LUTTE CONTRE LES NUISIBLES VIVANT DANS LE SOL
  申请人：SYNGENTA PARTICIPATIONS AG

  公开号：WO2014029710A2

  公开（公告）日：2014-02-27

  The present invention provides a method of controlling and/or preventing soil-dwelling pests in useful plants comprising applying to the locus of the useful plant or treating propagation material thereof, preferably a seed, with a compound of formula (I), wherein -B1-Β2-Β3- is -C=N-O-, -C=N-CH2-, or -N-CH2-CH2-; R1 is trifluoromethyl, difluoromethyl or chlorodifluoromethyl; R2 is group X X2 is C-X6 or nitrogen; X1, X3 and X6 are independently hydrogen, halogen or trihalomethyl, wherein at least one of X1, X3 and X6 is not hydrogen; A is selected from A1 to A5 Y1 is C-R6, CH or nitrogen; Y2 and Y3 are independently CH or nitrogen; wherein no more than two of Y1, Y2 and Y3 are nitrogen and wherein Y2 and Y3 are not both nitrogen; R5 is hydrogen, halogen, cyano, nitro, NH2, C1-C4alkyl, C1-C4aloalkyl, C3-C5cycloalkyl, C3- C5halocycloalkyl, C1-C2alkoxy, or C1-C2haloalkoxy; providing that when A is A3 or A4 R5 is not hydrogen; R6 when present together with R5 forms a -CH=CH-CH=CH- bridge; R7 is C1-C4alkyl; R8 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkoxy(C1-C4)alkyl, C1-C4alkylthio(C1-C4)alkyl, C1-C4alkylsulfmyl(C1-C4)alkyl, C1-C4alkylsulfonyl(C1-C4)alkyl, C3-C6cycloalkyl, C3-C6cycloalkyl(C1-C4)alkyl-, or tetrahydrofuranyl; R9 is C1-C4alkyl, C1-C4haloalkyl, C1-C4alkyl-O-CH2-, C1-C4haloalkyl-O-CH2-,C3-C6cycloalkyl, C3-C6cycloalkyl-CH2-, C1-C4alkyl-S-CH2-, C1-C4alkyl-S(O)-CH2-, or C1-C4alkyl-S(O2)-CH2; each Z is independently halogen, C1-C12alkyl or C1-C12alkyl substituted by one to five R12, nitro, C1-C12alkoxy or C1-C12alkoxy substituted by one to five R12 cyano, C1-C12alkylsulfinyl, C1-C12alkylsulfonyl, C1-C12haloalkylsulfinyl, C1-C12haloalkylsulfonyl, hydroxyl or thiol; each R12 is halogen, cyano, nitro, hydroxy, C1-C8alkoxy-, C1-C8haloalkoxy-, mercapto, C1-C8alkylthio-, or CpCghaloalkylthio; and k is 0, 1,2 or 3; wherein when the pest is corn rootworm, R8 is cyclopropyl when A is A2 and -B1-B2-B3- is -N-CH2-CH2-; Preferably the soil-dwelling pest is selected from corn rootworm, wireworms, grubs, in particular white grubs (e.g. Phyllophaga sp., Diloboderus sp., Popillia japonica), termites (in particular for sugar cane), subterraneous stinkbugs (e.g. Scaptocoris sp.), cutworms (e.g. agrotis sp.), millipedes (e.g. Julus sp.) and broca gigante (e.g. Telchin licus).