(4-methoxyphenyl) N'-hydroxycarbamimidate | 651306-29-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (4-methoxyphenyl) N'-hydroxycarbamimidate
• CAS: 651306-29-5
• 化学式: C₈H₁₀N₂O₃
• 分子量: 182.179
• InChiKey: QMWKBVBJLBDXPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.1
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  苯磺酰氯 、 (4-methoxyphenyl) N'-hydroxycarbamimidate 在 sodium hydroxide 作用下， 以 水 为溶剂， 生成 N-benzenesulfonyloxy-O-(4-methoxyphenyl)isourea
  参考文献：
  名称：

  Interaction of Aryloxychlorocarbenes with Acetylenedicarboxylate:  Novel Formation of Polyfunctional Butadienes and 8-Oxatricyclo[3.2.1.0^2.4]oct-6-enes

  摘要：

  The interaction of aryloxychlorocarbenes with dialkyl acetylenedicarboxylates has been examined. Thermolyses of 3-aryloxy-3-chlorodiazirines in the presence of acetylenedicarboxylate resulted in the formation of unexpected polyfunctional 1,3-butadienes and 8-oxatricyclo[3.2.1.0(2.4)]oct-6-enes or of 2-aryoxycarbonylmaleates dependent upon reaction conditions. This work confirmed the nucleophilicity of aryloxychlorocarbenes and underlined their synthetic potential.

  DOI：

  10.1021/jo0501792
• 作为产物：
  描述：

  4-甲氧基苯酚 在 盐酸羟胺 、 三乙胺 作用下， 以 甲醇 、 乙醚 为溶剂， 反应 1.5h， 生成 (4-methoxyphenyl) N'-hydroxycarbamimidate
  参考文献：
  名称：

  Interaction of Aryloxychlorocarbenes with Acetylenedicarboxylate:  Novel Formation of Polyfunctional Butadienes and 8-Oxatricyclo[3.2.1.0^2.4]oct-6-enes

  摘要：

  The interaction of aryloxychlorocarbenes with dialkyl acetylenedicarboxylates has been examined. Thermolyses of 3-aryloxy-3-chlorodiazirines in the presence of acetylenedicarboxylate resulted in the formation of unexpected polyfunctional 1,3-butadienes and 8-oxatricyclo[3.2.1.0(2.4)]oct-6-enes or of 2-aryoxycarbonylmaleates dependent upon reaction conditions. This work confirmed the nucleophilicity of aryloxychlorocarbenes and underlined their synthetic potential.

  DOI：

  10.1021/jo0501792

文献信息

• Interaction of Aryloxychlorocarbenes with Acetylenedicarboxylate:  Novel Formation of Polyfunctional Butadienes and 8-Oxatricyclo[3.2.1.0^2.4]oct-6-enes
  作者：Ying Cheng、Qing Zhu、Quan Song Li、Otto Meth-Cohn

  DOI：10.1021/jo0501792

  日期：2005.6.1

  The interaction of aryloxychlorocarbenes with dialkyl acetylenedicarboxylates has been examined. Thermolyses of 3-aryloxy-3-chlorodiazirines in the presence of acetylenedicarboxylate resulted in the formation of unexpected polyfunctional 1,3-butadienes and 8-oxatricyclo[3.2.1.0(2.4)]oct-6-enes or of 2-aryoxycarbonylmaleates dependent upon reaction conditions. This work confirmed the nucleophilicity of aryloxychlorocarbenes and underlined their synthetic potential.