1-(4-methoxybenzyl)-3,4-dibromo-1H-pyrrol-2(5H)-one | 1283089-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(4-methoxybenzyl)-3,4-dibromo-1H-pyrrol-2(5H)-one
• 英文别名: 3,4-dibromo-1-(4-methoxybenzyl)-1H-pyrrol-2(5H)-one；3,4-dibromo-1-[(4-methoxyphenyl)methyl]-2H-pyrrol-5-one
• CAS: 1283089-17-7
• 化学式: C₁₂H₁₁Br₂NO₂
• 分子量: 361.033
• InChiKey: NDNFBQCTHVHSTN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-methoxybenzyl)-3,4-dibromo-1H-pyrrol-2(5H)-one 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 potassium fluoride 、 1,3,5,7-四甲基-6-苯基-2,4,8-三氧杂-6-磷酰金刚烷 作用下， 以 甲苯 为溶剂， 反应 21.0h， 生成 1-(4-methoxybenzyl)-3,4-bis(4-chlorophenyl)-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Development of Methods for the Synthesis of Libraries of Substituted Maleimides and α,β-Unsaturated-γ-butyrolactams

  摘要：

  Synthetic methods for the preparation of maleimide and alpha,beta-unsaturated-gamma-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted alpha,beta-unsaturated-gamma-butyrolactams. The scope and limitations of the approaches are presented.

  DOI：

  10.1021/jo1025805
• 作为产物：
  描述：

  粘溴酸 、 4-甲氧基苄胺 在 sodium triacetylborohydride 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以76%的产率得到1-(4-methoxybenzyl)-3,4-dibromo-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Development of Methods for the Synthesis of Libraries of Substituted Maleimides and α,β-Unsaturated-γ-butyrolactams

  摘要：

  Synthetic methods for the preparation of maleimide and alpha,beta-unsaturated-gamma-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted alpha,beta-unsaturated-gamma-butyrolactams. The scope and limitations of the approaches are presented.

  DOI：

  10.1021/jo1025805

文献信息

• Development of Methods for the Synthesis of Libraries of Substituted Maleimides and α,β-Unsaturated-γ-butyrolactams
  作者：Emelia Awuah、Alfredo Capretta

  DOI：10.1021/jo1025805

  日期：2011.5.6

  Synthetic methods for the preparation of maleimide and alpha,beta-unsaturated-gamma-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted alpha,beta-unsaturated-gamma-butyrolactams. The scope and limitations of the approaches are presented.