2-(N,N-dimethylamino)-5-aminoethyl pyridine | 637015-71-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(N,N-dimethylamino)-5-aminoethyl pyridine
• 英文别名: 5-(2-Aminoethyl)-N,N-dimethylpyridin-2-amine
• CAS: 637015-71-5
• 化学式: C₉H₁₅N₃
• 分子量: 165.238
• InChiKey: AHADOMJOEYYNBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-chloropyrimidin-4-yl)(1-ethyl-2,3-dihydro-1H-benzimidazol-2-yl)acetonitrile 、 2-(N,N-dimethylamino)-5-aminoethyl pyridine 以the title compound was isolated, as a yellow solid in 78% yield (96% purity by HPLC)的产率得到[2-({2-[6-(dimethylamino)pyridin-3-yl]ethyl}amino)pyrimidin-4-yl](1-ethyl-1H-benzimidazol-2-yl)acetonitrile
  参考文献：
  名称：

  Benzimidazole Acetonitriles

  摘要：

  本发明涉及苯并咪唑乙腈以及含有该苯并咪唑乙腈的制药配方(I)。所述苯并咪唑乙腈在治疗由胰岛素抵抗或高血糖介导的代谢紊乱方面具有用途，包括2型糖尿病、不足的葡萄糖耐受性、胰岛素抵抗、肥胖症、多囊卵巢综合症（PCOS）(I)。本发明还涉及制备苯并噁唑乙腈的方法。其中G为嘧啶基；L为氨基，或者是一个3-8成员的杂环烷基，其中至少包含一个从N、O、S中选择的杂原子，或者L为一个酰胺基；R1选自包括或仅包括氢、磺酰基、氨基、羧基、氨基甲酰基、C1-C6烷基、C2-C6烯基、C2-C6炔基或C1-C6烷氧基、芳基、卤素、氰基或羟基的群；R2选自包括或仅包括氢、C1-C6烷基、C2-C6烯基、C2-C6炔基或C1-C6烷氧基的群。

  公开号：

  US20070203134A1

文献信息

• [EN] AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS<br/>[FR] DERIVES DE CYANURE D'AZOLE METHYLIDENE ET LEUR UTILISATION COMME MODULATEURS DE PROTEINE KINASE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2003106455A1

  公开（公告）日：2003-12-24

  The present invention is related to azole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such azole derivatives. Said azole derivatives are modulators of the protein kinase signalling pathways, particularly the one involving c-Jun N-terminal kinase and/or Glycogen Kinase Synthase 3. The present invention is furthermore related to novel azole derivatives as well as to methods of their preparation. X is O, S or NR0, with R0 being H or an unsubstituted or substituted C1 -C6 alkyl; A is 2-pyridyl, 3-pyridyl, 4-pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group.

  本发明涉及唑衍生物，尤其是用作药物活性化合物的唑衍生物，以及包含这种唑衍生物的药物制剂。所述唑衍生物是蛋白激酶信号通路的调节剂，尤其是涉及c-Jun N端激酶和/或糖原合酶3的那一种。本发明还涉及新颖的唑衍生物以及它们的制备方法。X是O、S或NR0，其中R0是H或未取代或取代的C1-C6烷基；A是2-吡啶基，3-吡啶基，4-吡啶基，吡啶唑基，吡唑啉基，吡嗪基或三嗪基团。
• [EN] PYRIDINYL ACETONITRILES<br/>[FR] ACÉTONITRILES DE PYRIDINYLE
  申请人：APPLIED RESEARCH SYSTEMS

  公开号：WO2004098607A1

  公开（公告）日：2004-11-18

  The present invention is related to pyridinyl acetonitriles as well as to pharmaceutical formulations containing such pyridinyl acetonitriles. Said pyridinyl acetonitriles are modulators of the protein kinase signalling pathways, particularly the one involving Glycogen Kinase Synthase 3 or JNK. The present invention is furthermore related to methods of preparing pyridinyl acetonitriles. X is a substituted or unsubstituted pyridinyl. G is an unsubstituted or substituted pyrimidinyl or triazinyl.

  本发明涉及吡啶基乙腈以及含有这种吡啶基乙腈的药物配方。所述吡啶基乙腈是蛋白激酶信号通路的调节剂，特别是涉及糖原激酶合成酶3或JNK的信号通路。本发明还涉及制备吡啶基乙腈的方法。X是取代或未取代的吡啶基。G是未取代或取代的嘧啶基或三嗪基。
• Azole methylidene cyanide derivatives and their use as protein kinase modulators
  申请人：Gaillard Pascale

  公开号：US20070123530A1

  公开（公告）日：2007-05-31

  An azole derivative of formula (I) a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of preparing the azole derivative of formula (I).

  一种公式（I）的唑类衍生物药物，其中包含公式（I）的唑类衍生物，使用公式（I）的唑类衍生物治疗疾病的方法以及制备公式（I）的唑类衍生物的方法。
• Pyridinyl acetonitriles
  申请人：Schwarz Matthias

  公开号：US20070060594A1

  公开（公告）日：2007-03-15

  The present invention is related to pyridinyl acetonitriles as well as to pharmaceutical formulations containing such pyridinyl acetonitriles. Said pyridinyl acetonitriles are modulators of the protein kinase signalling pathways, particularly the one involving Glycogen Kinase Synthase 3 or JNK. The present invention is furthermore related to methods of preparing pyridinyl acetonitriles. X is a substituted or unsubstituted pyridinyl. G is an unsubstituted or substituted pyrimidinyl or triazinyl.

  本发明涉及吡啶基乙腈及含有此类吡啶基乙腈的制药配方。所述吡啶基乙腈是蛋白激酶信号通路的调节剂，特别是涉及糖原合酶合成酶3或JNK的信号通路。本发明还涉及制备吡啶基乙腈的方法。其中X是取代或未取代的吡啶基。G是未取代或取代的嘧啶基或三嗪基。
• AZOLE METHYLIDENE CYANIDE DERIVATIVES AND THEIR USE AS PROTEIN KINASE MODULATORS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1527070A1

  公开（公告）日：2005-05-04