3-(3-bromo-4-fluorophenyl)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole | 1125812-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(3-bromo-4-fluorophenyl)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole
• 英文别名: 3-(3-bromo-4-fluorophenyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazole
• CAS: 1125812-44-3
• 化学式: C₁₆H₈BrCl₂F₄NO
• 分子量: 457.049
• InChiKey: KUVFDVDJQFPNMB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1H-1,2,4-三唑 、 3-(3-bromo-4-fluorophenyl)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 生成 3-[3-bromo-4-(1,2,4-triazol-1-yl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-1,2-oxazole
  参考文献：
  名称：

  4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

  摘要：

  Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.031
• 作为产物：
  描述：

  3,5-二氯苯硼酸频那醇酯 在 sodium hypochlorite 、 四(三苯基膦)钯 、 potassium hydroxide 作用下， 以 四氢呋喃 、 乙二醇二甲醚 、 水 为溶剂， 生成 3-(3-bromo-4-fluorophenyl)-5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)isoxazole
  参考文献：
  名称：

  4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

  摘要：

  Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.03.031

文献信息

• INSECTICIDAL ISOXAZOLINES
  申请人：MIHARA Jun

  公开号：US20110086886A2

  公开（公告）日：2011-04-14

  Novel isoxazolines of the formula (I) wherein A represents C or N; R represents haloalkyl; X represents halogen or haloalkyl; l represents 0, 1 or 2; Y represents halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, acylamino, alkoxycarbonylamino, haloalkoxycarbonyl-amino or alkylsulfonylamino; m represents 0, 1 or 2; and G represents any one selected from heterocyclic groups described in the specification; and intermediates, and a use thereof as insecticides and/or for controlling animal parasites.

  化合物的式子为（I），其中A代表C或N；R代表卤代烷基；X代表卤素或卤代烷基；l代表0、1或2；Y代表卤素、烷基、烷氧基、卤代烷基、氰基、硝基、氨基、酰胺基、烷氧羰基胺基、卤代烷氧羰基胺基或烷基磺酰胺基；m代表0、1或2；而G代表规范中所述的任意一种杂环基团。该化合物是昆虫杀虫剂和/或动物寄生虫控制剂的中间体，以及其用途。
• N-Methyl benzamide derivatives
  申请人：Coqueron Pierre-Yves

  公开号：US20100249191A1

  公开（公告）日：2010-09-30

  Novel isoxazolines of the formula (I) wherein A represents C or N; R represents haloalkyl; X represents halogen or haloalkyl; l represents 0, 1 or 2; Y represents halogen, alkyl, alkoxy, haloalkyl, cyano, nitro, amino, acylamino, alkoxycarbonylamino, haloalkoxycarbonyl-amino or alkylsulfonylamino; m represents 0, 1 or 2; and G represents any one selected from heterocyclic groups described in the specification; and intermediates, and a use thereof as insecticides and/or for controlling animal parasites.

  式(I)中的新异噁唑啉，其中A代表C或N；R代表卤代烷基；X代表卤素或卤代烷基；l代表0、1或2；Y代表卤素、烷基、烷氧基、卤代烷基、氰基、硝基、氨基、酰胺基、烷氧羰基胺基、卤代烷氧羰基胺基或烷基磺酰胺基；m代表0、1或2；G代表规范中描述的任意一个杂环基团；以及中间体，以及将其用作杀虫剂和/或控制动物寄生虫的用途。
• METHOD FOR PREPARING 5-HALOALKYL-4, 5-DIHYDROISOXAZOLE DERIVATIVES
  申请人：Annis Gary David

  公开号：US20120277442A1

  公开（公告）日：2012-11-01

  Disclosed is a method for preparing a compound of Formula 1 wherein R 1 is CHX 2 , CX 3 , CX 2 CHX 2 or CX 2 CX 3 ; each X is independently Cl or F; Z is optionally substituted phenyl; and Q is phenyl or 1-naphthalenyl, each optionally substituted as defined in the disclosure; comprising contacting a compound of Formula 2 with hydroxylamine in the presence of a base. The present invention also relates to novel compounds of Formula 2, useful as starting materials for the aforedescribed method.

  本发明揭示了一种制备式1化合物的方法，其中R1为CHX2，CX3，CX2CHX2或CX2CX3;每个X独立地为Cl或F;Z为可选取代的苯基;而Q为苯基或1-萘基，每个都可以根据公开说明进行取代;包括在碱存在下将式2化合物与羟胺接触。本发明还涉及新型式2化合物，用作上述方法的起始材料。
• METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES
  申请人：Annis Gary David

  公开号：US20100249424A1

  公开（公告）日：2010-09-30

  Disclosed is a method for preparing a compound of Formula 1 wherein R 1 is CHX 2 , CX 3 , CX 2 CHX 2 or CX 2 CX 3 ; each X is independently Cl or F; Z is optionally substituted phenyl; and Q is phenyl or 1-naphthalenyl, each optionally substituted as defined in the disclosure; comprising contacting a compound of Formula 2 with hydroxylamine in the presence of a base. The present invention also relates to novel compounds of Formula 2, useful as starting materials for the aforedescribed method.

  揭示了一种制备公式1化合物的方法，其中R1为CHX2，CX3，CX2CHX2或CX2CX3;每个X独立地为Cl或F;Z为可选取代的苯基;Q为苯基或1-萘基，每个均可按照本公开说明中定义进行取代;包括在碱的存在下将公式2化合物与羟胺接触。本发明还涉及公式2的新化合物，可用作上述方法的起始材料。
• Insecticidal isoxazolines
  申请人：Bayer CropScience AG

  公开号：EP2330106A1

  公开（公告）日：2011-06-08

  A isoxazoline compound of the following formula and its use as insecticide.

  下式的异噁唑啉化合物 及其作为杀虫剂的用途。