| 1263180-04-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1263180-04-6
• 化学式: C₂₀H₂₃NO₅
• 分子量: 357.406
• InChiKey: OJZGEDBJXMQCCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.41
• 重原子数：
  26.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  65.07
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  Methyl 6-[tert-butyl(dimethyl)silyl]oxy-2-[formyl-[(4-methoxyphenyl)methyl]amino]-3-hydroxy-2-(phenylmethoxymethyl)hex-4-ynoate 在 dodecacarbonyltetrarhodium(0) 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 2.0h， 生成 、 methyl 4-[2-[tert-butyl(dimethyl)silyl]oxyethylidene]-3-hydroxy-1-[(4-methoxyphenyl)methyl]-5-oxo-2-(phenylmethoxymethyl)pyrrolidine-2-carboxylate
  参考文献：
  名称：

  Synthetic studies of salinosporamide A through the intramolecular hydroamidation of alkynes

  摘要：

  Rhodium-catalyzed intramolecular hydroamidation of alkynes was carried out to construct the synthetic intermediates of a proteasome inhibitor, salinosporamide A. Several alkynyl formamides were synthesized and subjected to the hydroamidation reaction. Some derivatives with a methoxymethyl (MOM) or 2-methoxy-2-propyl (MOP) group near the reaction site were converted to the corresponding lactams in excellent yields. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.06.021