5′-bromo-3′,5-dimethyl-6-(3-methyl-4-pyridin-3-ylphenyl)-3,2′-bipyridine | 1359945-13-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5′-bromo-3′,5-dimethyl-6-(3-methyl-4-pyridin-3-ylphenyl)-3,2′-bipyridine
• 英文别名: 5’-bromo-3‘,5-dimethyl-6-(3-methyl-4-pyridin-3-ylphenyl)-3,2‘-bipyridine；5'-bromo-3',5-dimethyl-6-(3-methyl-4-pyridin-3-ylphenyl)-3,2'-bipyridine；5-Bromo-3-methyl-2-[5-methyl-6-(3-methyl-4-pyridin-3-ylphenyl)pyridin-3-yl]pyridine；5-bromo-3-methyl-2-[5-methyl-6-(3-methyl-4-pyridin-3-ylphenyl)pyridin-3-yl]pyridine
• CAS: 1359945-13-3
• 化学式: C₂₄H₂₀BrN₃
• 分子量: 430.347
• InChiKey: AUBDCMMAPLIWFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-溴-2-碘甲苯 在 potassium phosphate 、 四(三苯基膦)钯 、 正丁基锂 、 sodium carbonate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙二醇二甲醚 、 水 为溶剂， 反应 47.5h， 生成 5′-bromo-3′,5-dimethyl-6-(3-methyl-4-pyridin-3-ylphenyl)-3,2′-bipyridine 、 5'-(3-methyl-4-pyridin-3-ylphenyl)-3',5-dimethyl-6-(3-methyl-4-pyridin-3-ylphenyl)-3,2'-bipyridine
  参考文献：
  名称：

  Synthesis of new linear poly(phenylpyridyl) chains

  摘要：

  This paper describes for the first time an efficient approach of Suzuki Miyaura cross-coupling reaction leading to new mixed linear unsymmetric phenylpyridyl chains (garlands). We have studied the synthesis of new phenylpyridyl boronic species and their reactivity with a dihalogenated bipyridine to obtain four and six unit phenylpyridines. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.12.074

文献信息

• MCL-1 modulating compounds for cancer treatment
  申请人：Centre Régional de Lutte contre le Cancer - Centre François Baclesse

  公开号：EP2915811A1

  公开（公告）日：2015-09-09

  The invention relates to compounds of formula (I), and to their therapeutic use in the treatment of cancer: Wherein Y3, Y2, Ar1, Ar2, R1, R2, i, j, k, l are as defined in claim 1.

  本发明涉及式（I）化合物及其在治疗癌症中的治疗用途： 其中 Y3、Y2、Ar1、Ar2、R1、R2、i、j、k、l 如权利要求 1 所定义。
• MCL-1 MODULATING COMPOUNDS FOR CANCER TREATMENT
  申请人：Centre de Lutte Contre le Cancer Francois Baclesse

  公开号：EP3114119B1

  公开（公告）日：2019-05-01
• Synthesis of new linear poly(phenylpyridyl) chains
  作者：Serge Perato、Anne Sophie Voisin-Chiret、Jana Sopková-de Oliveira Santos、Rémi Legay、Hassan Oulyadi、Sylvain Rault

  DOI：10.1016/j.tet.2011.12.074

  日期：2012.2

  This paper describes for the first time an efficient approach of Suzuki Miyaura cross-coupling reaction leading to new mixed linear unsymmetric phenylpyridyl chains (garlands). We have studied the synthesis of new phenylpyridyl boronic species and their reactivity with a dihalogenated bipyridine to obtain four and six unit phenylpyridines. (C) 2011 Elsevier Ltd. All rights reserved.