(S)-5-N(G)-nitro-guanidino-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino}pentanoic acid methyl ester | 1207974-55-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-5-N(G)-nitro-guanidino-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino}pentanoic acid methyl ester
• CAS: 1207974-55-7
• 化学式: C₁₈H₂₁N₇O₉S₂
• 分子量: 543.538
• InChiKey: IKZWRNVMNXDQAM-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.81
• 重原子数：
  36.0
• 可旋转键数：
  12.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  235.76
• 氢给体数：
  5.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  (S)-5-N(G)-nitro-guanidino-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino}pentanoic acid methyl ester 在 盐酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以77%的产率得到(S)-5-N(G)-nitro-guanidino-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino}pentanoic acid hydrochloride
  参考文献：
  名称：

  Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

  摘要：

  We report the molecular design and synthesis of EG00229,2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1-ligand complexes by NMR spectroscopy and X-ray crystallography. Mutagenesis Studies localized VEGF-A binding in the NRP1 b1 domain and it peptide Fragment of VEGF-A was shown to bind at the same site by NMR, providing the basis for small molecule design. Compound 2 demonstrated inhibition of VEGF-A binding to NRP1 and attenuated VEGFR2 phosphorylation in endothelial cells. Inhibition of migration of endothelial cells was also observed. The viability of A549 lung carcinoma cells wits reduced by 2, and it increased the potency of the cytotoxic agents paclitaxel and 5-fluorouracil when given in combination. These studies provide the basis for design of specific small molecule inhibitors of ligand binding to NRP1.

  DOI：

  10.1021/jm901755g
• 作为产物：
  描述：

  L-NAME 、 3-(4-nitro-benzenesulfonylamino)thiophene-2-carboxylic acid 在 N,N-二异丙基乙胺 、 bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate 作用下， 以 二氯甲烷 为溶剂， 反应 16.33h， 以3%的产率得到(S)-5-N(G)-nitro-guanidino-2-{[3-(4-nitro-benzenesulfonylamino)thiophene-2-carbonyl]amino}pentanoic acid methyl ester
  参考文献：
  名称：

  Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

  摘要：

  We report the molecular design and synthesis of EG00229,2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1-ligand complexes by NMR spectroscopy and X-ray crystallography. Mutagenesis Studies localized VEGF-A binding in the NRP1 b1 domain and it peptide Fragment of VEGF-A was shown to bind at the same site by NMR, providing the basis for small molecule design. Compound 2 demonstrated inhibition of VEGF-A binding to NRP1 and attenuated VEGFR2 phosphorylation in endothelial cells. Inhibition of migration of endothelial cells was also observed. The viability of A549 lung carcinoma cells wits reduced by 2, and it increased the potency of the cytotoxic agents paclitaxel and 5-fluorouracil when given in combination. These studies provide the basis for design of specific small molecule inhibitors of ligand binding to NRP1.

  DOI：

  10.1021/jm901755g