5-(4-fluorophenyl)-2-phenyl-indolizine | 1603829-24-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 5-(4-fluorophenyl)-2-phenyl-indolizine
• 英文别名: 5-(4-Fluorophenyl)-2-phenylindolizine；5-(4-fluorophenyl)-2-phenylindolizine
• CAS: 1603829-24-8
• 化学式: C₂₀H₁₄FN
• 分子量: 287.336
• InChiKey: AZUXKUDKRPVPMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  溴化2-甲基-1-(2-羰基-2-苯基乙基)吡啶正离子 在 正丁基锂 、 四甲基乙二胺 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 17.25h， 生成 5-(4-fluorophenyl)-2-phenyl-indolizine
  参考文献：
  名称：

  Synthesis, photophysical, and electrochemical properties of 2,5-diaryl-indolizines

  摘要：

  A variety of novel 2,5-dialyl-indolizines have been prepared through the palladium-catalyzed cross-coupling reactions of organozinc reagents prepared from 2-aryl-indolizines with aromatic halides. The photophysical properties of representative compounds indicate that the 2,5-diaryl-indolizines are promising candidates to be used in optoelectronic devices and biomolecular labeling. In addition, cyclic voltammetry studies of some nitrophenyl-substituted indolizines have shown evidences of an oxidation process without the correspondent reduction peak suggesting a dimerization reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.11.105

文献信息

• Synthesis, photophysical, and electrochemical properties of 2,5-diaryl-indolizines
  作者：Mônica F.Z.J. Amaral、Laila A. Deliberto、Camila R. de Souza、Rose M.Z.G. Naal、Zeki Naal、Giuliano C. Clososki

  DOI：10.1016/j.tet.2013.11.105

  日期：2014.5

  A variety of novel 2,5-dialyl-indolizines have been prepared through the palladium-catalyzed cross-coupling reactions of organozinc reagents prepared from 2-aryl-indolizines with aromatic halides. The photophysical properties of representative compounds indicate that the 2,5-diaryl-indolizines are promising candidates to be used in optoelectronic devices and biomolecular labeling. In addition, cyclic voltammetry studies of some nitrophenyl-substituted indolizines have shown evidences of an oxidation process without the correspondent reduction peak suggesting a dimerization reaction. (C) 2013 Elsevier Ltd. All rights reserved.