6-phenyl-6-hepten-1-ol | 98525-79-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-phenyl-6-hepten-1-ol
• 英文别名: 6-phenylhept-6-en-1-ol
• CAS: 98525-79-2
• 化学式: C₁₃H₁₈O
• 分子量: 190.285
• InChiKey: NNFMZIIFPOYRJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.25
• 重原子数：
  14.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  6-phenyl-6-hepten-1-ol 在 草酰氯 、 二甲基亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 0.25h， 以92%的产率得到6-phenyl-6-heptenal
  参考文献：
  名称：

  Regiochemistry in the intramolecular cycloadditions of substituted 5-alkenyl and 6-alkenyl nitrones

  摘要：

  DOI：

  10.1021/jo00223a003
• 作为产物：
  描述：

  6-Phenyl-hept-6-enoic acid ethyl ester 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 5.0h， 以95%的产率得到6-phenyl-6-hepten-1-ol
  参考文献：
  名称：

  Regiochemistry in the intramolecular cycloadditions of substituted 5-alkenyl and 6-alkenyl nitrones

  摘要：

  DOI：

  10.1021/jo00223a003

文献信息

• Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols
  作者：Zhi-Min Chen、Margaret J. Hilton、Matthew S. Sigman

  DOI：10.1021/jacs.6b06994

  日期：2016.9.14

  An enantioselective redox-relay oxidative Heck arylation of 1,1-disubstituted alkenes to construct β-stereocenters was developed using a new pyridyl-oxazoline ligand. Various 1,2-diaryl carbonyl compounds were readily obtained in moderate yield and good to excellent enantioselectivity. Additionally, analysis of the reaction outcomes using multidimensional correlations revealed that enantioselectivity

  使用新的吡啶基恶唑啉配体开发了 1,​​1-二取代烯烃的对映选择性氧化还原中继氧化 Heck 芳基化以构建 β-立构中心。各种 1,2-二芳基羰基化合物很容易以中等收率和良好至优异的对映选择性获得。此外，使用多维相关性对反应结果的分析表明，对映选择性与 1,1-二取代烯醇的特定电子特征和配体的极化程度有关。
• Photoredox Synthesis of Thio‐Functionalized Cyclic Ethers Using <i>N</i>‐Sulfenyl Phthalimides as a Thiyl‐Radical Precursor
  作者：Maojian Lu、Rong‐Bin Liang、Can‐Ming Zhu、Qing‐Xiao Tong、Jian‐Ji Zhong

  DOI：10.1002/cjoc.202300118

  日期：2023.8

  A visible-light mediated exclusively regioselective synthesis of 2,2-disubstituted thio-functionalized tetrahydrofurans, tetrahydro- pyrans and oxepanes has been described through an operationally simple and mild photoredox protocol. Thiyl radical generated from N-phenylsulfenyl phthalimide by photoredox catalysis was proven to be the key reactive intermediate in this reaction.

  通过操作简单且温和的光氧化还原方案描述了可见光介导的 2,2-二取代硫代官能化四氢呋喃、四氢吡喃和氧杂环庚烷的完全区域选择性合成。N-苯基硫基邻苯二甲酰亚胺通过光氧化还原催化产生的硫基自由基被证明是该反应中的关键反应中间体。
• Access to Saturated Oxygen Heterocycles and Lactones via Electrochemical Sulfonylative Oxycyclization of Alkenes with Sulfonyl Hydrazides
  作者：Xiaoshuo Wang、Shubing Shu、Xiaojing Wang、Renshi Luo、Xiayi Ming、Tao Wang、Zhenming Zhang

  DOI：10.1021/acs.joc.2c02966

  日期：2023.2.17

  A facile electrochemical sulfonylative cycloetherification of linear unsaturated alcohols with sulfonyl hydrazides under mild conditions has been accomplished. This catalyst- and oxidant-free protocol proceeds via electro-oxidation, followed by radical addition, as well as an intramolecular oxygen nucleophilic process. This methodology is compatible with a broad substrate scope and good functional

  在温和条件下，已经完成了线性不饱和醇与磺酰肼的简便电化学磺酰化环醚化反应。这种无催化剂和氧化剂的方案通过电氧化进行，然后进行自由基加成，以及分子内氧亲核过程。该方法兼容广泛的底物范围和良好的官能团相容性，为饱和五、六、七和八元环氧杂环的合成提供了有价值和方便的合成工具。此外，在该电化学体系下，还建立了线性不饱和酸对内酯产物的磺酰化环酯化反应。此外，对照实验表明磺酰肼分子的 N-H 键不是必需的。
• Electrochemically Enabled Carbohydroxylation of Alkenes with H₂O and Organotrifluoroborates
  作者：Peng Xiong、Hao Long、Jinshuai Song、Yaohui Wang、Jian-Feng Li、Hai-Chao Xu

  DOI：10.1021/jacs.8b08592

  日期：2018.12.5

  Unprecedented hydroxy-alkynylation and -alkenylation reactions of arylalkenes have been developed through electrochemically enabled addition of an organotrifluoroborate reagent and H2O across the double bond of the alkene. The use of electrochemistry to promote these oxidative alkene 1,2-difunctionalization reactions not only obviates the need for transition-metal catalysts and oxidizing reagents but also ensures high regio- and chemoselectivity to afford homopropargylic or homoallylic alcohols. The possibility of extending the electro-chemical alkene difunctionalization strategy to other alkene carbo-heterofunctionalization reactions has been demonstrated.