4-(2-nitro-2-pyrrolidin-2-ylideneethyl)morpholine | 303016-97-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(2-nitro-2-pyrrolidin-2-ylideneethyl)morpholine
• CAS: 303016-97-9
• 化学式: C₁₀H₁₇N₃O₃
• 分子量: 227.263
• InChiKey: XABWRNLRQKHSGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  70.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吗啉 、 聚合甲醛 、 (2Z)-2-(硝基甲基烯)吡咯烷 以 乙醇 为溶剂， 反应 5.0h， 以71%的产率得到4-(2-nitro-2-pyrrolidin-2-ylideneethyl)morpholine
  参考文献：
  名称：

  Chemistry of Nitroenamines. Part 2. Synthesis of Saturated Pyrrolo-pyrimidines and -pyrazines

  摘要：

  New saturated pyrrolo-pyrimidines and pyrrolo-pyrazines were synthesized from 2-nitromethylene-pyrrolidine. Additionally, some simple aminomethylated derivatives of Mannich type were prepared. The nitro compounds were reduced into diastereomeric amines, which were separated and characterized structurally.

  DOI：

  10.3987/com-11-12246

文献信息

• Chemistry of Nitroenamines. Part 2. Synthesis of Saturated Pyrrolo-pyrimidines and -pyrazines
  作者：Pál Scheiber、Gábor Tóth、Mihály V. Pilipecz、Támas R. Varga、Péter Nemes

  DOI：10.3987/com-11-12246

  日期：——

  New saturated pyrrolo-pyrimidines and pyrrolo-pyrazines were synthesized from 2-nitromethylene-pyrrolidine. Additionally, some simple aminomethylated derivatives of Mannich type were prepared. The nitro compounds were reduced into diastereomeric amines, which were separated and characterized structurally.