(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(1-ethyl-propyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester | 696645-56-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(1-ethyl-propyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
• CAS: 696645-56-4
• 化学式: C₂₁H₄₁NO₄Si
• 分子量: 399.646
• InChiKey: UPKLKSUEMKKVBB-IAGOWNOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  27.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  55.84
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(1-ethyl-propyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 生成 [(2S,3R)-3-(1-Ethyl-propyl)-pyrrolidin-2-yl]-methanol
  参考文献：
  名称：

  Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants

  摘要：

  We recently described the identification of an optimized alpha-ketoamide warhead for our series of HCV NS3(.)4A inhibitors. We report herein a series of HCV protease inhibitors incorporating 3-alkyl-substituted prolines in P-2. These compounds show exceptional enzymatic and cellular potency given their relatively small size. The marked enhancement of activity of these 3-substituted proline derivatives relative to previously reported 4-hydroxyproline derivatives constitutes additional evidence for the importance of the S-2 binding pocket as the defining pharmacophore for inhibition of the NS3(.)4A enzyme. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.078
• 作为产物：
  描述：

  (2S,3R)-N-(叔-丁基氧羰基)-O-(叔-丁基)二甲基硅烷基-3,4-去氢-焦谷氨醇 、 1-ethylpropylzinc bromide 在 三氟化硼乙醚 、 三甲基氯硅烷 作用下， 以 四氢呋喃 为溶剂， 以37%的产率得到(2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(1-ethyl-propyl)-5-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Inhibitors of hepatitis C virus NS3·4A protease. Part 3: P2 proline variants

  摘要：

  We recently described the identification of an optimized alpha-ketoamide warhead for our series of HCV NS3(.)4A inhibitors. We report herein a series of HCV protease inhibitors incorporating 3-alkyl-substituted prolines in P-2. These compounds show exceptional enzymatic and cellular potency given their relatively small size. The marked enhancement of activity of these 3-substituted proline derivatives relative to previously reported 4-hydroxyproline derivatives constitutes additional evidence for the importance of the S-2 binding pocket as the defining pharmacophore for inhibition of the NS3(.)4A enzyme. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.01.078