3-bromo-5-ethoxy-4-[3-(tetrahydro-pyran-2-yloxy)benzyloxy]-benzaldehyde | 914094-54-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-bromo-5-ethoxy-4-[3-(tetrahydro-pyran-2-yloxy)benzyloxy]-benzaldehyde
• 英文别名: 3-Bromo-5-ethoxy-4-[[3-(oxan-2-yloxy)phenyl]methoxy]benzaldehyde
• CAS: 914094-54-5
• 化学式: C₂₁H₂₃BrO₅
• 分子量: 435.315
• InChiKey: OQBHAAMFBALDBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 4-Phenyl-5-Oxo-1,4,5,6,7,8-Hexahydroquinoline Derivatives for the Treatment of Infertility
  申请人：Grima Poveda Pedro Manuel

  公开号：US20080275042A1

  公开（公告）日：2008-11-06

  The present invention relates to 4-phenyl-5-oxo-1,4)5,6,7,8-hexahydroquinoline derivatives according to Formula I, Formula I or a pharmaceutically acceptable salt thereof, wherein R 1 is (1-6C)alkyl, (2-6C)alkenyl or (2-6C)aDcynyl; R 2 , R 3 are independently halogen, (1-4C)allyl, (2-4C)alkenyl, (2-4C)-alkynyl, (1-4C)aBcoxy, (3-4C)alkenyloxy or (3-4C)alkynyloxy; R 4 is phenyl or (2-5C)-heteroaryl, both substituted with R 7 and optionally substituted on the (hetero)aromatic ring with one or more substituents selected from hydroxy, amino, halogen, nitro, trifluoromethyl, cyano, (1-4C)alkyl, (1-4C)alkoxy, (1-4C)alkylthio and (di)(1-4C)-alkylamino. The invention also relates to pharmaceutical compositions comprising said derivatives, as well as to the use of these 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydro-quinoline derivatives in therapy, more specifically for the treatment of infertility

  本发明涉及公式I、公式II或其药学上可接受的盐的4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物，其中R1是(1-6C)烷基、(2-6C)烯基或(2-6C)炔基；R2、R3独立地为卤素、(1-4C)烯丙基、(2-4C)烯基、(2-4C)炔基、(1-4C)氧代丙基、(3-4C)烯氧基或(3-4C)炔氧基；R4是苯基或(2-5C)杂环芳基，均用R7取代，并且在(杂)芳香环上可选择地用一个或多个取代基取代，所述取代基选自羟基、氨基、卤素、硝基、三氟甲基、氰基、(1-4C)烷基、(1-4C)氧基、(1-4C)硫代烷基和(二)(1-4C)-烷基氨基。本发明还涉及包含上述衍生物的制药组合物，以及这些4-苯基-5-氧代-1,4,5,6,7,8-六氢喹啉衍生物在治疗中的应用，更具体地用于不孕症的治疗。
• 4-PHENYL-5-OXO-1,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES THE TREATMENT OF INFERTILITY
  申请人：N.V. Organon

  公开号：EP1881830B1

  公开（公告）日：2008-10-08
• US8022218B2
  申请人：——

  公开号：US8022218B2

  公开（公告）日：2011-09-20