1-(4-pyridylmethyl)indolin-5-yl 4-tetrahydropyranylmethylcarbamate | 1239325-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-pyridylmethyl)indolin-5-yl 4-tetrahydropyranylmethylcarbamate
• 英文别名: [1-(pyridin-4-ylmethyl)-2,3-dihydroindol-5-yl] N-(oxan-4-ylmethyl)carbamate
• CAS: 1239325-14-4
• 化学式: C₂₁H₂₅N₃O₃
• 分子量: 367.448
• InChiKey: WJIQDTCHOHVFHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  63.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• INDOLINE DERIVATIVES
  申请人：Kyoto University

  公开号：EP2394990A1

  公开（公告）日：2011-12-14

  The present invention provides a novel indoline derivative or a pharmacologically acceptable salt thereof or a solvate of the derivative or a salt thereof represented by the following formula (1) that has an excellent butyrylcholinesterase inhibitory activity. In the formula, R1 represents an alkyl group, a cycloalkyl group, a heterocycloalkyl group, an aryl group, a heteroaryl group, an arylalkyl group, a heteroarylalkyl group, a cycloalkylalkyl group, a heterocycloalkylalkyl group, a dihydrofurylalkyl group, an alkenyl group, a tetrahydronaphthyl group, or an indanyl group; R2 represents a hydrogen atom, an alkyl group, an arylalkyl group, a cycloalkylalkyl group, a heteroarylalkyl group, a heterocycloalkylalkyl group, an aryl group, or an acyl group; R3 each independently represents a hydrogen atom, an alkyl group, or a dialkylaminocarbonyl group; R4 each independently represents a hydrogen atom or an alkyl group; and R5 represents a hydrogen atom or an alkyl group. Each functional group may have a substituent.

  本发明提供了一种新颖的吲哚啉衍生物或其药理学上可接受的盐或该衍生物或其盐的溶液剂，由下式（1）表示，具有优异的丁酰胆碱酯酶抑制活性。式中，R1 代表烷基、环烷基、杂环烷基、芳基、杂芳基、芳烷基、杂芳烷基、环烷基、杂环烷基、二氢糠基、烯基、四氢萘基或茚基；R2 代表氢原子、烷基、芳烷基、环烷基、杂芳烷基、杂环烷基、芳基或酰基；R3 各自独立地代表氢原子、烷基或二烷基氨基羰基；R4 各自独立地代表氢原子或烷基；R5 代表氢原子或烷基。每个官能团都可以有一个取代基。