| 1296257-88-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1296257-88-9
• 化学式: C₁₀H₁₆O₅
• 分子量: 216.234
• InChiKey: SCIOPLVZPHJZFT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 sodium tetrahydroborate 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 (+/-)-cis-4-hydroxy-6-propyl-1-oxa-cyclohexan-2-one 、 (4R^*,6R^*)-4-hydroxy-6-n-propyl-1-oxacyclohexan-2-one
  参考文献：
  名称：

  Structural determination Vitex cymosa Bertero active principle: Diastereoselective synthesis of (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one and its antinociceptive activity

  摘要：

  The diastereoselective synthesis of (+/-)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one, as a mixture trans:cis (3:1), was accomplished using a protocol that combine the Prins cyclization and RuO4 oxidation. The synthesis this lactone allowed the elucidation of the correct structure of the substance isolated from the barks of Vitex cymosa. The delta-lactones mixture showed significant antinociceptive properties in preliminary tests using the tail flick model assay. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2010.05.001
• 作为产物：
  描述：

  在 sodium periodate 、 水 、 ruthenium trichloride 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 24.5h， 以85%的产率得到
  参考文献：
  名称：

  Structural determination Vitex cymosa Bertero active principle: Diastereoselective synthesis of (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one and its antinociceptive activity

  摘要：

  The diastereoselective synthesis of (+/-)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one, as a mixture trans:cis (3:1), was accomplished using a protocol that combine the Prins cyclization and RuO4 oxidation. The synthesis this lactone allowed the elucidation of the correct structure of the substance isolated from the barks of Vitex cymosa. The delta-lactones mixture showed significant antinociceptive properties in preliminary tests using the tail flick model assay. (C) 2010 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2010.05.001