| 214120-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧杂环己烷
• CAS: 214120-36-2
• 化学式: C₄₁H₇₈O₇Si₂
• 分子量: 739.237
• InChiKey: GZZJDTWUWZRRPW-LAJGTXMQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.26
• 重原子数：
  50.0
• 可旋转键数：
  14.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  75.61
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal 2,6-二甲基吡啶 、 lithium aluminium tetrahydride 、 正丁基锂 、 SO₂*pyridine 、 四丁基氟化铵 、 氢气 、 双氧水 、 碳酸氢钠 、 臭氧 、 二甲基亚砜 、 三乙胺 、 三苯基膦 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 、 乙醚 、 正己烷 、 二氯甲烷 、 水 、 乙酸乙酯 、 苯 为溶剂， 反应 33.0h， 生成 3-((2R,4S,4aR,5aR,7aS,9R,10S,12aR,13aS,14aR)-10-((tert-butyldimethylsilyl)oxy)-9-((Z)-hexa-3,5-dien-1-yl)-5a,10-dimethyl-4-((triisopropylsilyl)oxy)hexadecahydrooxepino[3,2-b]pyrano[2',3':5,6]pyrano[2,3-f]oxepin-2-yl)propan-1-ol
  参考文献：
  名称：

  Stereocontrolled Total Synthesis of Hemibrevetoxin B

  摘要：

  The stereocontrolled total synthesis of hemibrevetoxin B (1) has been achieved in 56 steps and 0.75% overall yield from D-mannose. The intramolecular reaction of gamma-alkoxyallylstannane with. aldehyde is a key step for the present total synthesis. Thus, the BF3. OEt2-mediated reaction of 24 gave 6 as a sole product. We encountered difficulty in the synthesis of gamma-alkoxyallylstannane 30 from the corresponding allyl ether 29 in which the gamma-alkoxy substituent became sterically quite bulky. This problem was solved by developing the acetal cleavage method for the synthesis of gamma-alkoxyallylstannanes. The cyclization of 38 proceeded smoothly to give the key intermediate 5 in a highly stereoselective manner. Construction of the alpha-vinyl aldehyde and (Z)-diene moieties were performed using Nicolaou's protocol.

  DOI：

  10.1021/jo9807619
• 作为产物：
  描述：

  3-[(2R,4S,4aR,5aR,8S,9R,10aS,11aR)-5a-Methyl-8-((Z)-3-tributylstannanyl-propenyloxy)-4-triisopropylsilanyloxy-2-(3-triisopropylsilanyloxy-propyl)-dodecahydro-1,5,10-trioxa-cyclohepta[b]naphthalen-9-yl]-propan-1-ol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Stereocontrolled Total Synthesis of Hemibrevetoxin B

  摘要：

  The stereocontrolled total synthesis of hemibrevetoxin B (1) has been achieved in 56 steps and 0.75% overall yield from D-mannose. The intramolecular reaction of gamma-alkoxyallylstannane with. aldehyde is a key step for the present total synthesis. Thus, the BF3. OEt2-mediated reaction of 24 gave 6 as a sole product. We encountered difficulty in the synthesis of gamma-alkoxyallylstannane 30 from the corresponding allyl ether 29 in which the gamma-alkoxy substituent became sterically quite bulky. This problem was solved by developing the acetal cleavage method for the synthesis of gamma-alkoxyallylstannanes. The cyclization of 38 proceeded smoothly to give the key intermediate 5 in a highly stereoselective manner. Construction of the alpha-vinyl aldehyde and (Z)-diene moieties were performed using Nicolaou's protocol.

  DOI：

  10.1021/jo9807619