1,1-bis(4-hydroxyphenyl)-2,2,2-trifluoroethane | 17619-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1-bis(4-hydroxyphenyl)-2,2,2-trifluoroethane
• 英文别名: 2,2-bis(4-hydroxyphenyl)-1,1,1-trifluoroethane；4,4'-(2,2,2-trifluorethylidene)diphenol；4-[2,2,2-trifluoro-1-(4-hydroxyphenyl)ethyl]phenol
• CAS: 17619-01-1
• 化学式: C₁₄H₁₁F₃O₂
• 分子量: 268.235
• InChiKey: KXBKTRIYEOEIHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-硝基邻苯二甲腈 、 1,1-bis(4-hydroxyphenyl)-2,2,2-trifluoroethane 在 sodium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 13.0h， 生成
  参考文献：
  名称：

  含烷基的具有自催化固化特性的邻苯二甲腈单体及其制备方法与应用

  摘要：

  本发明公开了一种含烷基的具有自催化固化特性的邻苯二甲腈单体及其制备方法与应用，所述含烷基的邻苯二甲腈单体，结构式如下：本发明所述有烷基的邻苯二甲腈单体中引入了催化单元烷基基团，因而可实现自催化固化，与现有邻苯二甲腈单体相比，在制备邻苯二甲腈树脂的应用中固化速率显著提高，所得到的邻苯二甲腈树脂的热稳定性及热氧稳定性优良。

  公开号：

  CN110256292A
• 作为产物：
  描述：

  1-甲氧基-4-[2,2,2-三氟-1-(4-甲氧基苯基)乙基]苯 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 以67%的产率得到1,1-bis(4-hydroxyphenyl)-2,2,2-trifluoroethane
  参考文献：
  名称：

  Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities

  摘要：

  17 beta-Estradiol (E2) is a natural steroid ligand for the structurally and physiologically independent estrogen receptors (ERs) ER alpha and ER beta. We recently observed that CF3-containing bisphenol AF (BPAF) works as an agonist for ERa but as an antagonist for ER beta. Similar results were also observed for the CCl3-containing bisphenol designated as HPTE. Both BPAF and HPTE are comprised of a tri-halogenated methyl group in the central alkyl moiety of their bisphenol structures, which strongly suggests that halogens contribute directly to the agonist/antagonist dual biological functions. We conducted this study to investigate the structure-activity relationships by assessing together newly synthesized CF3- and CBr3-containing bisphenol E analogs (BPE-X). We first tested bisphenols for their receptor binding ability and then for their transcriptional activities. Halogen-containing bisphenols were found to be fully active for ER alpha, but almost completely inactive for ER beta. When we examined these bisphenols for their inhibitory activities for E2 in ER beta, we observed that they worked as distinct antagonists. The ascending order of agonist/antagonist dual biological functions was BPE-F < BPE-Cl (HPTE) <= BPAF < BPE-Br, demonstrating that the electrostatic halogen bonding effect is a major driving force of the bifunctional ER alpha agonist and ER beta antagonist activities of BPAF.

  DOI：

  10.1016/j.bmc.2019.115274

文献信息

• Optical Element and Achromatic Lens
  申请人：Hatanaka Kunio

  公开号：US20090143560A1

  公开（公告）日：2009-06-04

  There are provided an optical element that comprises a polymer which has a structural unit derived from a specific dihydroxy compound typified by 2,2-bis(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoro propane (bisphenol AF) and in which the relationship between a refractive index n D and an Abbe number ν D satisfies the following formula (I): n D +0.0076×ν D ≦1.78  (I) and that is used for correction of chromatic aberration, and an achromatic lens using the optical element.

  提供了一种光学元件，其包括一种聚合物，该聚合物具有从特定的二羟基化合物中导出的结构单元，该二羟基化合物以2,2-双(4-羟基苯基)-1,1,1,3,3,3-六氟丙烷（双酚AF）为代表，并且折射率nD和阿贝数νD之间的关系满足以下公式（I）：nD+0.0076×νD≦1.78（I），并且用于矫正色差，以及使用该光学元件的消色差透镜。
• OPTICAL DEVICE AND ACHROMATIC LENS
  申请人：Teijin Chemicals, Ltd.

  公开号：EP1947131A1

  公开（公告）日：2008-07-23

  There are provided an optical element that comprises a polymer which has a structural unit derived from a specific dihydroxy compound typified by 2,2-bis(4-hydroxyphenyl)-1,1,1,3,3,3-hexafluoro propane (bisphenol AF) and in which the relationship between a refractive index nD and an Abbe number νD satisfies the following formula (I): nD+0.0076×νD≤1.78 and that is used for correction of chromatic aberration, and an achromatic lens using the optical element.

  提供了一种光学元件，它由一种聚合物组成，该聚合物的结构单元来源于一种特定的二羟基化合物，典型的是 2,2-双（4-羟基苯基）-1,1,1,3,3,3-六氟丙烷（双酚 AF），其中折射率 nD 和阿贝数 νD 之间的关系满足下式（I）：nD+0.0076×νD≤1.78。 用于校正色差，以及使用该光学元件的消色差透镜。
• POSITIVE PHOTOSENSITIVE RESIN COMPOSITION, CURED FILM FORMED BY CURING SAME, AND OPTICAL DEVICE EQUIPPED WITH SAME
  申请人：Toray Industries, Inc.

  公开号：EP3018532A1

  公开（公告）日：2016-05-11

  The purpose of the present invention is to develop a positive photosensitive resin composition which, without compromising high refractive index and high transparency characteristics, has excellent solvent resistance and resolution after pattern formation, and has high sensitivity to exposure, even after long-term storage at room temperature. This positive photosensitive resin composition is characterised by containing: a polysiloxane synthesised by hydrolysing and partially condensing a specific organosilane and an organosilane that has a carboxyl group and/or a dicarboxylic acid anhydride structure; (d) particles of one or more metal compounds selected from an aluminium compound, a tin compound, a titanium compound, and a zirconium compound, or composite particles of a silicon compound and one or more metal compounds selected from an aluminium compound, a tin compound, a titanium compound, and a zirconium compound; (b) a naphthoquinone diazide compound; and (c) a solvent.

  本发明的目的是开发一种正感光树脂组合物，它在不影响高折射率和高透明度特性的情况下，具有极佳的耐溶剂性和图案形成后的分辨率，并且即使在室温下长期储存，也具有极高的曝光灵敏度。这种正感光树脂组合物的特点是含有通过水解和部分缩合特定有机硅烷和具有羧基和/或二羧酸酐结构的有机硅烷而合成的聚硅氧烷；(d) 一种或多种选自铝化合物、锡化合物、钛化合物和锆化合物的金属化合物颗粒， 或硅化合物和一种或多种选自铝化合物、锡化合物、钛化合物和锆化合物的金属 化合物的复合颗粒； (b) 重氮化萘醌化合物；以及 (c) 溶剂。
• CURABLE RESIN, CURABLE RESIN COMPOSITION, CURED PRODUCT, ELECTRONIC DEVICE, LAMINATED BOARD MATERIAL, ELECTRONIC COMPONENT ENCAPSULANT, AND METHOD FOR PRODUCING CURABLE RESIN
  申请人：Central Glass Company, Limited

  公开号：EP4089131A1

  公开（公告）日：2022-11-16

  A curable resin represented by General Formula (1). In General Formula (1), R1 each independently represent a monovalent substituent (an alkyl group, an alkoxy group, a fluorine atom, and the like), m is 0 to 4, n is 0 to 40, and R2's are each independently a monovalent group including a polymerizable functional group.

  通式(1)所代表的可固化树脂。在通式（1）中，R1 各自独立地代表一个单价取代基（烷基、烷氧基、氟原子等），m 为 0 至 4，n 为 0 至 40，R2's 各自独立地代表一个包括可聚合官能团的单价基团。
• Heptaphosphorus-derived compounds as flame retardants
  申请人：BASF SE

  公开号：US10414985B2

  公开（公告）日：2019-09-17

  The invention relates to flame retardant compositions comprising heptaphosphorus-derived compounds and to novel heptaphosphorus-derived compounds. These heptaphosphorus-derived compounds are especially useful for the manufacture of flame retardant compositions based on thermoplastic polymers, especially polyolefin homo- and copolymers, polycondensates, such as polyamides, or polyesters and duroplastic polymers, such as the ones based on polyepoxides.

  本发明涉及包含七磷衍生化合物的阻燃组合物以及新型七磷衍生化合物。 这些七磷衍生化合物特别适用于制造基于热塑性聚合物的阻燃剂组合物，尤其是聚烯烃均聚物和共聚物、缩聚物（如聚酰胺）或聚酯和杜罗塑料聚合物（如基于聚环氧化物的聚合物）。