4-丁基苯-1,3-二胺 | 63921-07-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-丁基苯-1,3-二胺
• 英文名称: 2,4-diamino-1-n-butylbenzene
• 英文别名: 2,4-Diamino-1-n-butylbenzol；1,3-Benzenediamine, 4-butyl-；4-butylbenzene-1,3-diamine
• CAS: 63921-07-3
• 化学式: C₁₀H₁₆N₂
• 分子量: 164.25
• InChiKey: KJVCRAMHOORMSK-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于二氯甲烷、乙酸乙酯、甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-丁基苯-1,3-二胺 、 草酰氯单乙酯 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Ethyl 2-[4-butyl-3-[(2-ethoxy-2-oxoacetyl)amino]anilino]-2-oxoacetate
  参考文献：
  名称：

  N,N'-(phenylene)dioxamic acids and their esters as antiallergy agents

  摘要：

  A series of dialkyl N,N'-(m-phenylene)dioxamates was synthesized by treatment of the requisite m-phenylenediamines with an alkyloxalyl chloride in the presence of triethylamine. Hydrolysis with sodium hydroxide solution gave the corresponding N,N'-(m-phenylene)dioxamic acids. Several N,N'-(p-phenylene)dioxamic acids were synthesized also in the same manner starting with the requisite p-phenylenediamines. These compounds were tested in the rat passive cutaneous anaphylaxis (PCA) assay. When tested iv, activity was found in the N,N'-(m-phenylene) dioxamic acids up to 2500 times that shown by disodium cromoglycate [50% inhibition at 0.001 mg/kg for N,N'-(2-chloro-5-cyano-m-phenylene)dioxamic acid (compound 61)]. Oral activity was seen in this series of compounds with duration of activity up to 120 min. Oral activity was detected in diethyl N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate (compound 38) at levels of drug as low as 0.1 mg/kg.

  DOI：

  10.1021/jm00207a016
• 作为产物：
  描述：

  1-propoxy-2,4-dinitrobenzene 生成 4-丁基苯-1,3-二胺
  参考文献：
  名称：

  Pharmaceutical compositions comprising pyridoquinoline derivatives and

  摘要：

  含有2,7-二羧基-4,9-二羟基吡啶并[2,3-g]喹啉衍生物或2,8-二羧基-4,6-二羟基吡啶并[3,2-g]喹啉衍生物的药物组合物。这些化合物对由抗原-抗体反应引发的综合症或疾病具有活性。还公开了制备这些化合物的方法。

  公开号：

  US03984551A1

文献信息

• Verfahren zur Herstellung von gegebenenfalls zelligen Polyurethan-Polyharnstoff-Formkörpern
  申请人：BASF Aktiengesellschaft

  公开号：EP0109624A2

  公开（公告）日：1984-05-30

  Die Erfindung betrifft ein Einstufen-Verfahren zur Herstellung von zelligen oder vorzugsweise kompakten Polyurethan-Polyharnstoff-Formkörpern, vorzugsweise mit Hilfe der Reaktionsspritzgußtechnik, durch Umsetzung von organischen Polyisocyanaten, Polyolen und gegebenenfalls substituierten Diaminoazobenzolen, vorzugsweise 4,4'- und/oder 2,4'-Diaminoazobenzolen, Diaminoazopyridinen und/oder deren Oxide in Gegenwart von Katalysatoren sowie gegebenenfalls Treibmitteln, Hilfs- und Zusatzstoffen.

  本发明涉及一种生产蜂窝状聚氨酯-聚脲模塑件的一步法工艺，最好采用反应注 塑技术，在催化剂和可选发泡剂、助剂和添加剂的存在下，使有机多异氰酸酯、多元 醇和可选取代的二氨基偶氮苯，最好是 4,4'-和/或 2,4'-二氨基偶氮苯、二氨基偶氮吡啶和/ 或其氧化物发生反应。
• Wholly aromatic polyamide composition and filaments or fibres thereof
  申请人：TEIJIN LIMITED

  公开号：EP0007631B1

  公开（公告）日：1983-03-02
• Substituted m-phenylenediamines
  申请人：THE DOW CHEMICAL COMPANY

  公开号：EP0082258B1

  公开（公告）日：1986-02-19
• DYE COMPOSITION USING AT LEAST ONE COUPLER OF META-PHENYLENEDIAMINE TYPE SUBSTITUTED IN POSITION 4 IN A MEDIUM COMPRISING A FATTY SUBSTANCE, PROCESSES AND DEVICE
  申请人：L'Oréal

  公开号：EP2950774B1

  公开（公告）日：2018-07-25
• METHOD FOR DYEING KERATINOUS SUBSTANCES STARTING FROM COLOURED OLIGOMERS AND/OR POLYMERS RESULTING FROM META-PHENYLENEDIAMINES, COMPOSITION AND DYEING AGENT
  申请人：L'OREAL

  公开号：US20160310383A1

  公开（公告）日：2016-10-27

  A subject-matter of the invention is a) a method for dyeing keratinous substances starting from a dyeing agent chosen from coloured oligomers and polymers obtained from the polycondensation of i) meta-phenylenediamine (MPD) couplers in the presence of ii) one or more ingredients chosen from radical initiators and/or chemical oxidizing agents, b) a composition comprising one or more coloured oligomers and/or one or more coloured polymers as defined above and c) a coloured oligomeric or polymeric dyeing agent obtained by reaction between i) and ii) as defined above, and the use of the coloured oligomer(s) or polymer(s) for dyeing keratinous substances. The dyeing method and the composition according to the invention make it possible in particular to obtain a long-lasting colouration on keratinous fibres which is vivid, chromatic and/or homogeneous.