methyl 1-butylaziridine-2-carboxylate | 35197-07-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 1-butylaziridine-2-carboxylate
• 英文别名: 1-Butyl-ethylenimin-carbonsaeure-2-methylester；1-butyl-aziridine-2-carboxylic acid methyl ester；Methyl 1-butylaziridine-2-carboxylate
• CAS: 35197-07-0
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: RSWVKOAHYLHGFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methyl 1-butylaziridine-2-carboxylate 、 2-(三甲基硅)苯基三氟甲烷磺酸盐 在 四丁基氟化铵 、 水 作用下， 以 四氢呋喃 为溶剂， 以73%的产率得到methyl 3-(butyl(phenyl)amino)-2-fluoropropanoate
  参考文献：
  名称：

  One-pot synthesis of α-fluoro-β-amino acid and indole spiro-derivatives via CN bond cleavage/formation

  摘要：

  In this Letter, the alpha-fluoro-beta-amino acid directives were elegantly generated via a novel strategy of the nucleophilic addition of arynes and aziridines. C-N bonds were successfully constructed with high efficiency. With the utilization of TABF hydrate as the fluorinated reagent, fluorine atom could be assembled into the target molecule selectively. Interestingly, under another condition, unexpected indole spiro-derivatives could be achieved successfully. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.09.130

文献信息

• DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS
  申请人：Molteni Valentina

  公开号：US20090012094A1

  公开（公告）日：2009-01-08

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文介绍了一种包含二芳胺结构特征的化合物。还介绍了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的制药组合物和药物。本文还介绍了使用这种化合物、制药组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• US7563894B2
  申请人：——

  公开号：US7563894B2

  公开（公告）日：2009-07-21
• US7592349B2
  申请人：——

  公开号：US7592349B2

  公开（公告）日：2009-09-22
• US7638523B2
  申请人：——

  公开号：US7638523B2

  公开（公告）日：2009-12-29