3-hydroxy-estra-1,3,5(10)-triene[17,16-c]pyrazole-5'-carbonitrile | 1367825-92-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-hydroxy-estra-1,3,5(10)-triene[17,16-c]pyrazole-5'-carbonitrile
• CAS: 1367825-92-0
• 化学式: C₂₀H₂₁N₃O
• 分子量: 319.406
• InChiKey: FSMKVMPRQKACQO-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  9-methyl-5-(trifluoromethyl)-6,7-diazapentacyclo[10.8.0.02,9.04,8.013,18]icosa-4(8),5,13(18),14,16-pentaen-16-ol 在 氨 、 水 作用下， 反应 12.0h， 以6%的产率得到3-hydroxy-estra-1,3,5(10)-triene[17,16-c]pyrazole-5'-carbonitrile
  参考文献：
  名称：

  Synthesis of 3-Cyanopyrazoles from 3-Trifluoromethyl-pyrazoles via Direct Ammonolysis Reaction

  摘要：

  A simple and green method to prepare 3-cyanopyrazoles in aqueous ammonia from easy-obtained 3-trifluoromethyl-pyrazoles was explored. Most substrates got acceptable yields. The hydrogen position of Nl-H on cyanopyrazoles was assigned by X-ray crystal structure analysis.

  DOI：

  10.3987/com-11-12399