4-丙基-2-嘧啶胺 | 28732-64-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 4-丙基-2-嘧啶胺
• 英文名称: 4-propyl-pyrimidin-2-ylamine
• 英文别名: 4-Propyl-pyrimidin-2-ylamin；2-Amino-4-n-propylpyrimidin；2-Amino-4-propyl-pyrimidin；2-Amino-4-propylpyrimidin；4-Propylpyrimidin-2-amine
• CAS: 28732-64-1
• 化学式: C₇H₁₁N₃
• mdl: MFCD14707184
• 分子量: 137.184
• InChiKey: CZSMIYBZIJBZKR-UHFFFAOYSA-N

物化性质

• 熔点：
  122 °C
• 沸点：
  296.3±33.0 °C(Predicted)
• 密度：
  1.076±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  51.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933599090

反应信息

• 作为反应物：
  描述：

  4-丙基-2-嘧啶胺 在 吡啶 作用下， 生成 4-amino-N-(4-propyl-pyrimidin-2-yl)-benzenesulfonamide
  参考文献：
  名称：

  N¹-Sulfanilylamino-alkyl-pyrimidines

  摘要：

  DOI：

  10.1021/ja01262a034
• 作为产物：
  描述：

  2-amino-4-propylpyrimidine-5-carboxylic acid 反应 1.5h， 以71%的产率得到4-丙基-2-嘧啶胺
  参考文献：
  名称：

  Schenone, Pietro; Sansebastiano, Laura; Mosti, Luisa, Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 295 - 305

  摘要：

  DOI：

文献信息

• AMINO ACID LIPIDS AND USES THEREOF
  申请人：Marina Biotech, Inc.

  公开号：US20140037714A1

  公开（公告）日：2014-02-06

  This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本公开提供了一系列氨基酸脂质化合物和组合物，可用于药物传递、治疗以及疾病和病症的诊断和治疗。氨基酸脂质化合物和组合物可用于向细胞、组织、器官和受试者传递各种药物，例如核酸治疗药物。
• TYROSINE-BASED LIPIDS FOR DELIVERY OF THERAPEUTICS
  申请人：Marina Biotech, Inc.

  公开号：US20160206739A1

  公开（公告）日：2016-07-21

  This disclosure provides a range of tyrosine amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects.

  本披露提供了一系列酪氨酸氨基酸脂类化合物和组合物，可用于药物输送、治疗以及疾病和病症的诊断和治疗。这些氨基酸脂类化合物和组合物可用于将各种药剂如核酸治疗剂输送至细胞、组织、器官和受试者。
• Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics
  申请人：Marina Biotech, Inc.

  公开号：EP2902013A1

  公开（公告）日：2015-08-05

  Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition. An efficiency for delivering a drug cargo is provided. Compositions can include a liposome containing one or more carrier particles, each carrier particle having an active agent and a peptide, wherein the ratio of the mass of the peptide plus the mass of the liposome to the mass of the active agent is less than about 15.

  将活性剂水溶液与有机溶剂中含有一种或多种 DILA2 氨基酸化合物或脂质的脂质体形成成分溶液接触，形成撞击流，制备治疗药物脂质体给药工艺和组合物。使用包括流速、pH 值和培养期的方案来控制用于治疗的脂质体成分的形成。可收集并培养撞击流，以制备封装活性剂的脂质体制剂。该组合物可以用缓冲液淬火，并通过切向流、重滤和其他方法进行过滤，最后制成药物组合物。提供了一种高效的药物货物运输方法。组合物可包括含有一种或多种载体颗粒的脂质体，每种载体颗粒具有活性剂和肽，其中肽的质量加上脂质体的质量与活性剂的质量之比小于约 15。
• COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS
  申请人：Lantheus Medical Imaging, Inc.

  公开号：EP3567029A1

  公开（公告）日：2019-11-13

  The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.

  本发明涉及合成和使用成像剂或其前体的系统、组合物和方法。成像剂前体可通过本文所述方法转化为成像剂。在某些情况下，成像剂富含 18F。在某些情况下，成像剂可用于成像受试者感兴趣的区域，包括但不限于心脏、心血管系统、心脏血管、大脑和其他器官。在一些实施方案中，提供了用于评估受试者部分灌注和神经支配失配的方法和组合物。
• Sulfonamido Derivatives of Pyrimidines
  作者：James M. Sprague、L. W. Kissinger、Robert M. Lincoln

  DOI：10.1021/ja01856a046

  日期：1941.11