4-丙基-L-脯氨酸 | 15385-24-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 4-丙基-L-脯氨酸
• 英文名称: 4ξ-n-Propyl-L-prolin
• 英文别名: 4-propyl-L-proline；(2S)-4-propylpyrrolidine-2-carboxylic acid
• CAS: 15385-24-7
• 化学式: C₈H₁₅NO₂
• 分子量: 157.213
• InChiKey: DQHUOKOFSXEEAW-MLWJPKLSSA-N

物化性质

• 熔点：
  222 °C (decomp)
• 沸点：
  279.1±33.0 °C(Predicted)
• 密度：
  1.040±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

文献信息

• Collagen mimics
  申请人：Raines T. Ronald

  公开号：US20070275897A1

  公开（公告）日：2007-11-29

  Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly) n , where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.

  揭示了一种具有三肽单元的新型胶原模拟物，其化学式为（Xaa-Yaa-Gly）n，其中Xaa或Yaa位置中的一个是体积庞大的非电子吸引脯氨酸衍生物。通过在原生胶原螺旋中的Xaa或Yaa位置之一替换脯氨酸衍生物，仅通过立体效应相对于先前已知的胶原相关三肽螺旋，可以增加螺旋的稳定性。还揭示了制备新型胶原模拟物的方法。
• STABILIZATION OF THE COLLAGEN TRIPLE HELIX BY O-METHYLATION OF HYDROXYPROLINE RESIDUES
  申请人：Raines Ronald T.

  公开号：US20090264626A1

  公开（公告）日：2009-10-22

  This invention relates to a collagen polypeptide comprising a tripeptide motif having the formula (ProYaaGly) n , where Yaa is an O-methylated amino acid residue and “n” is the number of motif repeats. Preferred O-methylated amino acid residues at the Yaa position include (2S,4R)-4-methoxyproline. Other suitable amino acid residues at that position include O-mono or O-di-halogenated methylproline. Also, disclosed is a method of making a synthetic or a semi-synthetic collagen polypeptide molecule having increased stability relative to natural collagen. The strengthened collagen molecules are suitable for use in biomaterials for the medical field or in leather-related products prepared by the tanning industry.

  本发明涉及一种胶原蛋白多肽，其包含具有公式（ProYaaGly）n的三肽基序，其中Yaa是O-甲基化的氨基酸残基，“n”是基序重复的次数。在Yaa位置的首选O-甲基化氨基酸残基包括（2S，4R）-4-甲氧基脯氨酸。该位置上的其他适当氨基酸残基包括O-单或O-双卤代甲基脯氨酸。此外，还揭示了一种制备具有相对于天然胶原蛋白增强稳定性的合成或半合成胶原蛋白分子的方法。强化的胶原分子适用于医学领域的生物材料或由制革工业制备的皮革相关产品。
• Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
  申请人：UNIVERSITY OF MIAMI

  公开号：EP0048159A2

  公开（公告）日：1982-03-24

  Novel inhibitors of angiotensin converting enzyme are disclosed which have the general formula Wherein X = X, O or NR9, R4 and R5 form with -N-C- a 4-6 membered ring structure as described and the other R substituents are selected from a variety of disclosed groups.

  已公开的新型血管紧张素转换酶抑制剂具有通式 其中 X = X、O 或 NR9，R4 和 R5 与 -N-C- 形成所述的 4-6 分子环结构，其他 R 取代基选自已公开的各种基团。
• COLLAGEN MIMICS
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20180030115A1

  公开（公告）日：2018-02-01

  Novel collagen mimics are disclosed with a tripeptide unit having the formula (Xaa-Yaa-Gly) n , where one of the positions Xaa or Yaa is a bulky, non-electron withdrawing proline derivative. By substituting a proline derivative at either the Xaa or Yaa position in the native collagen helix, the stability of the helix is increased due solely to steric effects relative to prior known collagen-related triple helices. Methods are also disclosed for making the novel collagen mimics.
• US4766110A
  申请人：——

  公开号：US4766110A

  公开（公告）日：1988-08-23