作者:Koen J. Van Aken、Lieven Meerpoel、Georges J. Hoornaert
DOI:10.1016/s0040-4039(00)79064-2
日期:1992.5
Electrophilic catalysis is shown to give selective substitution of the imidoyl chloride group in 3,5-dichloro-2H-1,4-oxazin-2-ones, avoiding competitive reactions of the nucleophile with the lactone function. With other nucleophiles (SCN-, CH2N2) cyclisations involving the azadiene- or the imine function take place. Cycloaddition of the obtained oxazinones to acetylenic compounds provides polyfunctionalized pyridines.