| 1597573-41-5

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• CAS: 1597573-41-5
• 化学式: C₇H₁₅N₃O₃
• 分子量: 189.214
• InChiKey: LKBDIAPMKLZRIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.06
• 重原子数：
  13.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  87.45
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1,4-二(溴甲基)苯 、 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以64.1%的产率得到1-(((1-azido-3-(1-ethoxyethoxy)propan-2-yl)oxy)methyl)-4-(bromomethyl)benzene
  参考文献：
  名称：

  Synthesis of Linear, Cyclic, Figure-Eight-Shaped, and Tadpole-Shaped Amphiphilic Block Copolyethers via t-Bu-P₄-Catalyzed Ring-Opening Polymerization of Hydrophilic and Hydrophobic Glycidyl Ethers

  摘要：

  This paper describes the synthesis of systematic sets of figure-eight- and tadpole-shaped amphiphilic block copolyethers (BCPs) consisting of poly(decyl glycidyl ether) and poly[2-(2-(2-methoxyethoxy)ethoxy)ethyl glycidyl ether], together with the corresponding cyclic counterparts, via combination of the t-Bu-P-4-catalyzed ring-opening polymerization (ROP) and click cyclization. The clickable linear BCP precursors, with precisely controlled azido and ethynyl group placements as well as a fixed molecular weight and monomer composition (degree of polymerization for each block was adjusted to be around 50), were prepared by the t-Bu-P-4-catalyzed ROP with the aid of functional initiators and terminators. The click cyclization of the precursors under highly diluted conditions produced a series of cyclic, figure-eight-, and tadpole-shaped BCPs with narrow molecular weight distributions of less than 1.06. Preliminary studies of the BCPs self-assembly in water revealed the significant variation in their cloud points depending on the BCP architecture, though there were small architectural effects on their critical micelle concentration and morphology of the aggregates.

  DOI：

  10.1021/ma500494e
• 作为产物：
  描述：

  2-((1-乙氧基乙氧基)甲基)环氧乙烷 在 sodium azide 、 氯化铵 作用下， 以 水 、 异丙醇 为溶剂， 以44.4%的产率得到
  参考文献：
  名称：

  Synthesis of Linear, Cyclic, Figure-Eight-Shaped, and Tadpole-Shaped Amphiphilic Block Copolyethers via t-Bu-P₄-Catalyzed Ring-Opening Polymerization of Hydrophilic and Hydrophobic Glycidyl Ethers

  摘要：

  This paper describes the synthesis of systematic sets of figure-eight- and tadpole-shaped amphiphilic block copolyethers (BCPs) consisting of poly(decyl glycidyl ether) and poly[2-(2-(2-methoxyethoxy)ethoxy)ethyl glycidyl ether], together with the corresponding cyclic counterparts, via combination of the t-Bu-P-4-catalyzed ring-opening polymerization (ROP) and click cyclization. The clickable linear BCP precursors, with precisely controlled azido and ethynyl group placements as well as a fixed molecular weight and monomer composition (degree of polymerization for each block was adjusted to be around 50), were prepared by the t-Bu-P-4-catalyzed ROP with the aid of functional initiators and terminators. The click cyclization of the precursors under highly diluted conditions produced a series of cyclic, figure-eight-, and tadpole-shaped BCPs with narrow molecular weight distributions of less than 1.06. Preliminary studies of the BCPs self-assembly in water revealed the significant variation in their cloud points depending on the BCP architecture, though there were small architectural effects on their critical micelle concentration and morphology of the aggregates.

  DOI：

  10.1021/ma500494e