1-(123I)iodanyl-4-methylbenzene | 102582-61-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(123I)iodanyl-4-methylbenzene
• CAS: 102582-61-6
• 化学式: C₇H₇I
• 分子量: 214.133
• InChiKey: UDHAWRUAECEBHC-VYJFISKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  potassium 4-tolyltriolborate 在 sodium iodide 、 chloroamine-T 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 0.33h， 以85%的产率得到1-(123I)iodanyl-4-methylbenzene
  参考文献：
  名称：

  No-carrier-added radioiodination of triolborates, water-soluble complexes of boronic acids

  摘要：

  已开发出一种便捷快速的合成方法，能够从水溶性复合物中制备标记有碘-123的芳基和杂芳基碘化物，这些复合物源自芳基和杂芳基硼酸。版权所有 © 2010 John Wiley & Sons, Ltd.

  DOI：

  10.1002/jlcr.1831

文献信息

• Novel Imaging Agents for Fibrosis
  申请人：Chettibi Salah

  公开号：US20080279765A1

  公开（公告）日：2008-11-13

  The present invention provides a novel imaging agent targeting the mannose-6-phosphate (M6P) receptor suitable for the non-invasive visualization of fibrosis. A method for the preparation of the imaging agent is also provided by the invention, as well as a precursor for use in said method. The invention also provides a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition in which the mannose-6-phosphate receptor is upregulated is provided.

  本发明提供了一种新型的成像剂，针对甘露糖-6-磷酸（M6P）受体，适用于非侵入性可视化纤维化。本发明还提供了一种用于制备成像剂的方法，以及用于该方法的前体。本发明还提供了包括成像剂的药物组合物以及用于制备药物组合物的工具包。在另一个方面，本发明提供了利用成像剂进行体内成像和制备用于诊断甘露糖-6-磷酸受体上调病况的药物的方法。
• Diagnostic imaging agents with mmp inhibitory activity
  申请人：Storey Anthony

  公开号：US20070071670A1

  公开（公告）日：2007-03-29

  The present invention relates to the field of diagnostic imaging. Specifically, the invention relates to the diagnostic imaging of diseases where specific matrix metalloproteinases are known to be involved. One embodiment of the invention is a compound having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the diagnostic imaging agent of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. The pharmaceutical composition of the invention may be used in the diagnosis of diseases where specific matrix metalloproteinases are known to be involved.

  本发明涉及诊断成像领域。具体来说，该发明涉及已知涉及特定基质金属蛋白酶的疾病的诊断成像。该发明的一个实施例是一种具有适用于诊断成像的基质金属蛋白酶抑制活性的化合物。本发明还揭示了一种包含该发明的诊断成像试剂的药物组合物，其适合于哺乳动物的给药形式。此外，该发明还揭示了用于合成该发明的诊断成像试剂的中间体以及用于制备该发明的药物组合物的试剂盒。该发明的药物组合物可用于诊断已知涉及特定基质金属蛋白酶的疾病。
• Radiolabelling Method Using Polymers
  申请人：Gacek Michel

  公开号：US20080305042A1

  公开（公告）日：2008-12-11

  The present invention provides a method for the preparation of radioisotopically-labelled imaging agent compositions. The method uses precursors which are bound to soluble polymers, so that the radiolabelling reaction is carried out in solution. Also described are radiopharmaceutical compositions, automated versions of the radiolabelling method and disposable cassettes for use in the automated method.

  本发明提供了一种制备放射性同位素标记成像剂组合物的方法。该方法使用与可溶性聚合物结合的前体物质，使放射标记反应在溶液中进行。还描述了放射性药物组合物、放射标记方法的自动化版本以及用于自动化方法的一次性盒子。
• IMAGING THE CENTRAL NERVOUS SYSTEM
  申请人：Jones Paul Alexander

  公开号：US20110027178A1

  公开（公告）日：2011-02-03

  The present invention provides novel compounds which may be used as in vivo imaging agents. The compounds of the invention are useful in a method to image the expression of P2X 7 receptors in a subject, as a means to facilitate the diagnosis of a range of disease states.

  本发明提供了新型化合物，可用作体内成像剂。本发明的化合物可用于成像受体P2X7在受试者中的表达，作为一种促进多种疾病状态诊断的手段。
• TETRACYCLIC INDOLE DERIVATIVES AS IN VIVO IMAGING AGENTS AND HAVING PERIPHERALBENZODIAZEPINE RECEPTOR AFFINITY (PBR)
  申请人：Arstad Erik

  公开号：US20090220420A1

  公开（公告）日：2009-09-03

  The present invention provides novel tetracyclic indole compounds of Formula (I) either as in vivo imaging agents or as therapeutic agents. A method for the preparation of the in vivo imaging agent compound is also provided by the invention, as well as a precursor for use in said method. Pharmaceutical compositions comprising the compounds of the invention are additionally provided. Where the pharmaceutical composition comprises a compound suitable for in vivo imaging, a kit is provided for the preparation of the pharmaceutical composition. In a further aspect, use of the compound for in vivo imaging or treatment of conditions associated with PBR is provided.

  本发明提供了新型四环吲哚化合物（I）作为体内成像剂或治疗剂。本发明还提供了一种用于制备体内成像剂化合物的方法，以及用于该方法的前体。此外，还提供了包含本发明化合物的制药组合物。其中，如果制药组合物包含适用于体内成像的化合物，则提供用于制备制药组合物的工具包。在另一个方面，提供了将该化合物用于体内成像或治疗与PBR相关病症的用途。