1-(5-Bromothiophen-2-yl)pyrrolidin-2-one | 264194-56-1

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 1-(5-Bromothiophen-2-yl)pyrrolidin-2-one
• CAS: 264194-56-1
• 化学式: C₈H₈BrNOS
• 分子量: 246.128
• InChiKey: RUXQMMAPXBIJAG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  48.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴噻吩 、 2-吡咯烷酮 在 copper diacetate 、 三苯基膦 、 silver carbonate 作用下， 以 1,4-二氧六环 、 氯苯 为溶剂， 反应 20.0h， 以59%的产率得到1-(5-Bromothiophen-2-yl)pyrrolidin-2-one
  参考文献：
  名称：

  Copper-catalyzed oxidative C‒H, N‒H coupling of azoles and thiophenes

  摘要：

  C-H, N-H coupling of azole and thiophene derivatives takes place in the presence of a catalytic amount of Cu(OAc)(2) and an additive. The reaction of azoles smoothly occurs with several amines and amides catalyzed by 20 mol % of Cu(OAc)(2)-2PPh(3) and 4 equiv of NaOAc under O-2 or in the presence of Ag2CO3 under N-2. The coupling reaction leads to a facile synthesis of a N-substituted analogue of 2,5-diarylthiazole, which shows photoluminescent properties with extended pi-conjugation. Spectroscopic characteristics of the obtained thiazole derivatives are discussed by measurements of UV-vis absorption and photoluminescent spectra. Under the reaction conditions using Ag2CO3 as an additive and Cu(OAc)2-2PPh3 as a catalyst, thiophene derivatives also react with 2-pyrrolidone to undergo C-H, N-H amidation. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.03.001

文献信息

• SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES
  申请人：Syngenta Limited

  公开号：EP1119547A1

  公开（公告）日：2001-08-01
• [EN] SUBSTITUTED PYRROLIDINONE, THIAZOLIDINONE OR OXAZOLIDINONE AS HERBICIDES<br/>[FR] PYRROLIDINONE, THIAZOLIDINONE OU OXAZOLIDINONE SUBSTITUEE UTILISEE EN TANT QU'HERBICIDES
  申请人：ZENECA LTD

  公开号：WO2000021928A1

  公开（公告）日：2000-04-20

  A compound of general formula (I) wherein Y is O, S or CH2; R1 is an optionally substituted aryl or heteroaromatic ring, wherein the optional substituents are selected from halogen, C¿1?-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy or C1-C4 haloalkoxy; R?2 and R3¿ are independently selected from hydrogen or halogen; and R?4 and R5¿ are independently selected from halogen. The compounds are useful as herbicides.