16-hydroxy-hexadec-2t-enoic acid | 122396-74-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 16-hydroxy-hexadec-2t-enoic acid
• 英文别名: (2E)-16-hydroxyhexadec-2-enoic acid；(E)-16-hydroxyhexadec-2-enoic acid
• CAS: 122396-74-1
• 化学式: C₁₆H₃₀O₃
• 分子量: 270.412
• InChiKey: YSNNTXAJZMWJCI-WYMLVPIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  19
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Isolation and structural elucidation of the cytostatic linear depsipetide dolastatin 14
  申请人：ARIZONA BOARD OF REGENTS

  公开号：EP0428367A1

  公开（公告）日：1991-05-22

  A new cytostatic depsipeptide, designated "dolastatin 14", was isolated from the Indian Ocean shell-less mollusk Dolabella auricularia. Dolastatin 14 inhibited growth of the PS leukemia with ED₅₀ 0.0018 g/mL. Pharmaceutical preparations and therapeutic regimens utilizing Dolastatin 14, its synthetic counterpart and pharmaceutically active derivatives are disclosed. Dolastatin 14 has the structural formula:

  从印度洋无壳软体动物 Dolabella auricularia 中分离出一种新的细胞抑制性去肽，命名为 "dolastatin 14"。多拉斯汀 14 能抑制 PS 白血病的生长，ED₅₀ 0.0018 克/毫升。本研究公开了利用多拉他汀 14、其合成对应物和药用活性衍生物的药物制剂和治疗方案。多拉他汀 14 的结构式为
• Ophthalmic formulation
  申请人：Millar Thomas

  公开号：US10385003B2

  公开（公告）日：2019-08-20

  Disclosed herein is an ophthalmic formulation comprising a compound of formula (I): wherein R1 is a linear or branched C9-C33 alkyl or a linear or branched C9-C33 alkenyl with 1 to 4 double bonds; R2 is a linear or branched C9-C19 alkyl or a linear or branched C9-C19 alkenyl with 1 to 4 double bonds; and an ophthalmologically acceptable carrier.

  本文公开了一种眼科制剂，它包含式（I）化合物：其中 R1 是直链或支链 C9-C33 烷基或具有 1 至 4 个双键的直链或支链 C9-C33 烯基；R2 是直链或支链 C9-C19 烷基或具有 1 至 4 个双键的直链或支链 C9-C19 烯基；以及眼科可接受载体。
• Methods of producing omega-hydroxylated fatty acid derivatives
  申请人：GENOMATICA, INC.

  公开号：US10711288B2

  公开（公告）日：2020-07-14

  The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.

  本公开涉及欧米伽羟化脂肪酸衍生物及其生产方法。在此，本发明公开了一种新颖且环保的生产方法，可提供高纯度和高产率的ω-羟基化脂肪酸衍生物。还包括通过选择性发酵生产欧米伽羟化脂肪酸衍生物的重组微生物。
• Omega-hydroxylase-related fusion polypeptide variants with improved properties
  申请人：GENOMATICA, INC.

  公开号：US10787648B2

  公开（公告）日：2020-09-29

  The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

  本公开涉及欧米伽羟化酶相关融合多肽，该多肽在重组宿主细胞中表达时可提高欧米伽羟化脂肪酸衍生物的产量。本发明还涉及用于表达欧米伽羟化酶相关融合多肽的微生物，以生产欧米伽羟化脂肪酸衍生物。
• Omega-hydroxylase-related fusion polypeptides with improved properties
  申请人：Genomatica, Inc.

  公开号：US11421206B2

  公开（公告）日：2022-08-23

  The disclosure relates to omega-hydroxylase-related fusion polypeptides that result in improved omega-hydroxylated fatty acid derivative production when expressed in recombinant host cells. The disclosure further relates to microorganisms for expressing the omega-hydroxylase-related fusion polypeptides for the production of omega-hydroxylated fatty acid derivatives.

  本公开涉及欧米伽羟化酶相关融合多肽，该多肽在重组宿主细胞中表达时可提高欧米伽羟化脂肪酸衍生物的产量。本发明还涉及用于表达欧米伽羟化酶相关融合多肽的微生物，以生产欧米伽羟化脂肪酸衍生物。