申请人:Asahi Kasei Pharma Corporation
公开号:EP2006271A9
公开(公告)日:2009-07-29
[Object] To provide a compound having prostaglandin production-suppressing action and leukotriene production-suppressing action.
[Means for solution] A compound represented by the formula (I):
[In the formula, ---- represents a single bond, or a double bond, Link represents a single bond, or a saturated or unsaturated straight hydrocarbon having 1 or 2 carbon atoms, W represents a single bond, oxygen atom, sulfur atom, N(Rw) etc., Rw represents hydrogen atom, an alkyl group having 1 to 8 carbon atoms etc, Rs represents -D-Rx etc., D represents a single bond, oxygen atom, sulfur atom etc., Rx represents a linear or branched saturated alkyl group having 3 to 8 carbon atoms etc., one of V1 and V2 represents Zx, and the other represents AR, Zx represents hydrogen atom, a linear or branched saturated alkyl group having 1 to 4 carbon atoms etc., AR represents a partially unsaturated or completely unsaturated condensed bicyclic carbon ring or heterocyclic ring, and Y represents hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms etc.], or a salt thereof.
[目的]提供一种具有抑制前列腺素生成作用和抑制白三烯生成作用的化合物。
[解决方法] 一种由式(I)表示的化合物:
[式中,---- 代表单键或双键,Link 代表单键或具有 1 或 2 个碳原子的饱和或不饱和直链烃,W 代表单键、氧原子、硫原子、N(Rw)等,Rw 代表氢原子、具有 1 至 8 个碳原子的烷基等,Rs 代表-D-Rx 等,D 代表单键、氧原子、硫原子等、Rx 代表具有 3 至 8 个碳原子的直链或支链饱和烷基等,V1 和 V2 中的一个代表 Zx,另一个代表 AR,Zx 代表氢原子、具有 1 至 4 个碳原子的直链或支链饱和烷基等,AR 代表部分不饱和或完全不饱和的缩合双环碳环或杂环,Y 代表氢原子、具有 1 至 4 个碳原子的低级烷基等],或其盐。