(Z)-3-Iodopropenamide | 137627-61-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (Z)-3-Iodopropenamide
• 英文别名: (Z)-3-iodo-2-propenamide；(Z)-3-iodoprop-2-enamide
• CAS: 137627-61-3
• 化学式: C₃H₄INO
• 分子量: 196.975
• InChiKey: SARNVGDLQWJMJH-UPHRSURJSA-N

物化性质

• 沸点：
  294.1±32.0 °C(Predicted)
• 密度：
  2.157±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(3,4,8,9-tetrahydro-6-methoxy-3,3,8,8-tetramethylfuro[2,3-h]isoquinolin-1-yl)benzenamine 、 (Z)-3-Iodopropenamide 在 三乙胺 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， 生成 N-Ethyl-3-(3,4,8,9-tetrahydro-6-methoxy-3,3,8,8-tetramethylfuro[2,3-h]isoquinolin-1-yl)benzenamine
  参考文献：
  名称：

  FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF

  摘要：

  公开号：

  EP1270577B1
• 作为产物：
  描述：

  丙炔酰胺 在 溶剂黄146 、 lithium iodide 作用下， 反应 22.0h， 以98%的产率得到(Z)-3-Iodopropenamide
  参考文献：
  名称：

  A novel regio- and stereospecific hydrohalogenation reaction of 2-propynoic acid and its derivatives

  摘要：

  2-Propynoic acid and its derivatives are hydrohalogenated regio- and stereospecifically by reaction with lithium halides in acetic acid, or preferably with 1 equiv of acetic acid in refluxing CH3CN, to afford the thermodynamically unfavorable (Z)-3-halopropenoic acids and their derivatives as sole products. A rationale for the regio- and stereospecificity is briefly discussed.

  DOI：

  10.1021/jo00028a055

文献信息

• Furoisoquinoline derivatives, process for producing the same and use thereof
  申请人：——

  公开号：US20040092582A1

  公开（公告）日：2004-05-13

  A compound having a partial structure represented by Formula: 1 or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.

  一种具有部分结构式1表示的化合物或其盐具有优异的磷酸二酯酶（PDE）IV抑制作用，并可用作预防或治疗炎症性疾病的药物，例如支气管哮喘、慢性阻塞性肺疾病（COPD）、类风湿性关节炎、自身免疫疾病、糖尿病等。
• Coupling Reactions of Cephalosporin Sulfones:  A Stable 3-Stannylated Cephem
  作者：John D. Buynak、Lakshminarayana Vogeti、Hansong Chen

  DOI：10.1021/ol016142v

  日期：2001.9.1

  [GRAPHICS]The first stable 3-metalated cephalosporin is reported and shown to be an excellent synthetic precursor to a number of prospective beta -lactamase inhibitors.
• Enantioselective Synthesis of (−)-Basiliskamide A
  作者：Ming Chen、William R. Roush

  DOI：10.1021/ol300282e

  日期：2012.3.16

  Basiliskamide A is an antifungal polyketide natural product isolated by Andersen and co-workers from a Bacillus laterosporus isolate, PNG-276. A nine-step enantioselective synthesis of (-)-basiliskamide A is reported, starting from commercially available beta-hydroxy ester 7. The synthesis features a highly diastereoselective mismatched double asymmetric delta-stannylallylboration reaction of aldehyde 5 with the bifunctional allylborane reagent 4.
• Wojcik, Jacek; Stefaniak, Lech; Witanowski, Michal, Bulletin of the Polish Academy of Sciences: Chemistry, 1984, vol. 32, # 1-2, p. 85 - 95
  作者：Wojcik, Jacek、Stefaniak, Lech、Witanowski, Michal、Webb, Graham A.

  DOI：——

  日期：——
• WOJCIK, J.;STEFANIAK, L.;WITANOWSKI, M.;WEBB, G. A., BULL. POL. ACAD. SCI. CHEM., 1984, 32, N 1-2, 85-95
  作者：WOJCIK, J.、STEFANIAK, L.、WITANOWSKI, M.、WEBB, G. A.

  DOI：——

  日期：——